Results 221 to 230 of about 4,454,003 (248)

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

Experimental feasibility of dual-energy X-ray tomography for two-phase density analysis in bentonite during water infiltration. [PDF]

Sci Rep
Yliharju J, Harjupatana T, Rajala E, Tanttu J, Miettinen A.   +4 more
europepmc   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Aquaculture facility-specific microbiota shape the zebrafish gut microbiome. [PDF]

Anim Microbiome
Evens KC, Bakke I, Bohannan BJM.
europepmc   +1 more source

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

A lab-scale biofiltration system for mitigating diluted methane emissions. [PDF]

HardwareX
Geiger T, González C, Ali J, Vasco-Correa J.   +3 more
europepmc   +1 more source

Quantitative Integration of FRET and Molecular Dynamics for Modeling Flexible Peptides. [PDF]

J Phys Chem B
Roccatano D.
europepmc   +1 more source

Inductively coupled plasma mass spectrometry as a sensitive non-radioactive alternative for quantitative analysis in drug metabolism studies based on fluorine detection. [PDF]

Anal Bioanal Chem
Wouters S, Cuyckens F.
europepmc   +1 more source

A new in silico model to precisely design focused ultrasound brain therapies. [PDF]

Med Phys
Conti A, Grossi M, De Andrade PC, Duggento A, Toschi N.   +4 more
europepmc   +1 more source

Chemical Shift Separated and Compensated Ultra-Short Echo-Time Imaging. [PDF]

Magn Reson Med
Krämer M, Cui L, Reichenbach JR, Sommer S.   +3 more
europepmc   +1 more source