Results 221 to 230 of about 6,390,138 (247)

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

The Potential for Absolute Temperature Imaging Based on Brain Metabolites Using an FID-Shifting Approach in Gradient Echo Planar Spectroscopic Imaging (GREPSI). [PDF]

Magn Reson Med
Parker DL, Odéen H, Wong P, Kim SE, Judd W, Blatter DD.   +5 more
europepmc   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

ECHIDNA: Extreme Climate Historical and Future Indices Data under Numerous Approaches across Major Chinese River Basins Based on CMIP6 Multi-Model Ensemble. [PDF]

Sci Data
Xinlong L, Ling K, Hao C.
europepmc   +1 more source

Potential role of anaerobic plant-associated bacteria in naphthenic acid degradation. [PDF]

Appl Environ Microbiol
Morvan S, Correa-García S, Bergeron M-J, Trepanier K, Vander Meulen IJ, Atugala DM, Tremblay J, Ahad JME, Headley JV, Gieg LM, Degenhardt D, Martineau C, Yergeau É.   +12 more
europepmc   +1 more source

Gastric Tissue Biomonitoring Identifies Tissue-Specific Metal Profiles Associated with <i>Helicobacter pylori</i> Infection. [PDF]

Toxics
Aydin T, Turksoy VA.
europepmc   +1 more source

Effects of <i>Amomum tsaoko</i> on Chicken and Beef Quality During Stewing: Insights from Microstructure, Proteomics, and Molecular Docking. [PDF]

Foods
Zhou S, Zhao S, Zhou R, Gong C, Chen Y, Luo H, Du Z, Shen Y, Lu L, Duan S, Dong J, Yang R, Fang C, Ge Y.   +13 more
europepmc   +1 more source

The Explore2-2022 climate projections dataset for impact studies over France. [PDF]

Data Brief
Marson P, Soubeyroux JM, Corre L, Samacoïts R, Sauquet E, Robin Y, Vrac M.   +6 more
europepmc   +1 more source