Results 301 to 310 of about 1,530,827 (359)

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Data for: Water Conservation through Simplified Drip Irrigation Scheduling for Cotton Cultivation in Uzbekistan

Jamshid Shukurullaev, Ahmad Hamidov, Anton Liutin   +2 more
openalex   +1 more source

Mixed-method approach for sustainable water conservation efforts among Malaysian generation Y with social cognitive theory

Ganesh Ramasamy, Elango Natarajan, Haslinda Abdullah   +2 more
openalex   +2 more sources

Soil and Water Conservation in the Upper Paraguay River Basin: Examples from Mato Grosso do Sul, Brazil

, 2012
Carlos Nobuyoshi Ide, Fábio Luiz Teixeira Gonçalves, Giancarlo Lastoria, Humberto C. [UNESP] Val, Jhonatan Silva, Jorge L. Steffen, Luiz Augusto Araujo do Val, Maria Dolores dos Santos Barzotto [UNESP] Ribeiro, Sandra G. [UNESP] Gabas, Synara A. O. Broch   +9 more
openalex   +1 more source

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Evolution of water conservation in humans

Current Biology, 2021
To sustain life, humans and other terrestrial animals must maintain a tight balance of water gain and water loss each day.1-3 However, the evolution of human water balance physiology is poorly understood due to the absence of comparative measures from other hominoids.
Herman Pontzer, Mary H. Brown, Brian M. Wood, David A. Raichlen, Audax.Z.P. Mabulla, Jacob A. Harris, Holly Dunsworth, Brian Hare, Kara Walker, Amy Luke, Lara R. Dugas, Dale Schoeller, Jacob Plange-Rhule, Pascal Bovet, Terrence E. Forrester, Melissa Emery Thompson, Robert W. Shumaker, Jessica M. Rothman, Erin Vogel, Fransiska Sulistyo, Shauhin Alavi, Didik Prasetyo, Samuel S. Urlacher, Stephen R. Ross   +23 more
openaire   +4 more sources