Results 51 to 60 of about 6,083,325 (309)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Geogenic contamination [PDF]

, 2015
Contamination in drinking water, both chemical and microbiological, can originate from a range of sources, most of which are anthropogenic, such as agriculture, industry or human settlements (Fig. 2.1).
Johnston, Richard B. (author), Johnson, C. Annette (author), Bretzler, Anja (author)   +2 more
core   +1 more source

Measurement of Ellman’s Essay Using a Smartphone Camera Coupled with an Image Processing Technique in CIE-LAB Color Space for the Detection of Two Pesticides in Water

Analytica
In recent years, Thailand’s agriculture sector has seen a significant rise in pesticide usage due to its vital role in the economy and global food trade. However, the uncontrolled use of pesticides poses severe health and environmental risks.
Chiravoot Pechyen, Calin Trif, Benya Cherdhirunkorn, Surachet Toommee, Yardnapar Parcharoen   +4 more
doaj   +1 more source

Sensors for Chemical Contaminants in Water

The Boolean: Snapshots of Doctoral Research at University College Cork, 2022
Long-term exposure to chemical contaminants in our drinking water can have adverse effects on human health. Such exposure has been linked to cancers, neurological diseases, and cardiovascular diseases. Examples of chemical contaminants found in our water systems include nitrates, heavy metals such as lead, and disinfectant by-products.
openaire   +2 more sources

A Review of Groundwater Contamination in West Bank, Palestine: Quality, Sources, Risks, and Management

, 2022
The contamination and shortages of drinking water in the West Bank are among the most important challenges facing the Palestinian National Authority (PA) and the population residing in all sectors.
Ashraf Zohud, Lubna Alam
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Assessment of Microbial Contamination in the Infulene River Basin, Mozambique

, 2023
Water microbial contamination is one of the major threats to human health. The study focus is on Infulene River Basin, a urban catchment with mainly informal settlements, with limited water supply and sanitation. In the catchment there are two wastewater
Sífia Rapulua, Nídia Cangi Vaz, Hélio Nhantumbo, José Sumbana, Cândido Manuel, Jéssica Langa, Dominic Joaquim, Ricardo Santos, Silvia Monteiro, Clemêncio Nhantumbo, Mery Rodrigues, Michaque Dosse, Dinis Juízo   +12 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The Spread of Mycobacterium chimaera from Heater–Cooler Units and Infection Risk in Heart Surgery: Lessons from the Global Outbreak?

Pathogens
Mycobacterium chimaera (MC), a member of the Mycobacterium avium complex, can cause infections in patients after open-heart surgery due to contaminated heater–cooler units (HCUs).
Anna Maria Spagnolo, Osvalda De Giglio, Giuseppina Caggiano, Francesco D’Agostini, Mariano Martini, Davide Orsini, Sebastiano La Maestra   +6 more
doaj   +1 more source