Results 211 to 220 of about 15,661,404 (348)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Water content alters soil organic carbon metabolism via microbial traits in Tibetan alpine peatlands. [PDF]

Sci Rep
Jiang W, Xiong M, Feng S, Liu Q, Chen Y, Zou S, Kang D.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Study on unfrostered water content and strength characteristics of saturated sandstone during thawing process. [PDF]

Sci Rep
Li Z, Yang G, Wang B, Wang J.
europepmc   +1 more source

The use of an e-tongue for discriminating ethanol/water mixtures and determination of their water content

, 2016
Dalton P. de Queiroz, A. O. Florentino, Juliana Catarina Bruno b, J. A. F. D. Silva, Antonio Riul, José A. Giacometti   +5 more
semanticscholar   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A Thermo-TDR Sensor for Simultaneous Measurement of Unfrozen Water Content and Thermal Conductivity of Frozen Soil. [PDF]

Sensors (Basel)
Liu P, Fan S, Mu Q, Zhang Q, Tang L, Liu J, Cui F, Liu Z, Wang X.   +8 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Cervical intradural disc herniation: a new diagnostic clue based on MRI T2 hyperintensity and intraoperative increased water content in the intervertebral disc-a case report and mechanistic insights. [PDF]

Front Surg
Guo G, Shi X, Qiu Y, Gao D, Fang P, Ma H, Liu G.   +6 more
europepmc   +1 more source