Results 91 to 100 of about 3,075,262 (303)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Modelling Radiatively Active Water Ice Clouds in the Martian Water Cycle [PDF]
, 2011 The aim of this project is to model the Martian water cycle, including radiatively active water ice clouds, to interpret new observations from Mars Climate Sounder.
Lewis, Stephen +3 more
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
MATEC Web of Conferences, 2018 The intense climate changes and human activities have a great impact on the variation of the runoff of the coastal area of South China. In this work, the Soil and Water Assessment Tool (SWAT) is used to quantify the impact of land use and climate change ...
Yang Mingzhi +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Northward expansion of multiple cropping systems exacerbates agricultural water stress
Agricultural Water ManagementRising temperature promotes the expansion and shift of multiple cropping systems (CS), which increases food production while consuming more water, thereby having a disadvantage on water-scarce areas.
Linghui Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
A Novel Approach for Evaluating Seismic Performance of Frame-Type Underground Structures
BuildingsThis paper examines the seismic performance evaluation methodology for underground structures. Through analysis of seismic damage and failure characteristics of underground structures, this study proposes a novel evaluation approach for frame-type ...
Zhong-Yang Yu +5 more
doaj +1 more source
Integrated urban water management in Texas: a review to inform a one water approach for the future [PDF]
, 2018 Texas has considerable experience grappling with historic droughts as well as flooding associated with tropical storms and hurricanes, yet the State’s water management challenges are projected to increase.
Ashmore, Jacqueline +2 more
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