Results 111 to 120 of about 3,075,262 (303)

Ratio of natural isotopes of nitrogen. I. Primary results: soils of Dombes [Translation from: Revue d'Ecologie et de Biologie du Sol 14, 279-287, 1977] [PDF]

, 1980
Utilization of the heavy isotope of nitrogen as a tracer has found numerous applications in soil biology. It allows better definition of different stages of the nitrogen cycle, in particular the immobilization-mineralization cycle.
Chalamet, A., Domenach, A. M., Pachiaudi, C.   +2 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Probabilistic assessment of water network influence zones and ecosystem responses following the middle route of the South-to-North Water Diversion Project

Big Earth Data
Large-scale inter-basin water transfer (IBWT) projects fundamentally reshape regional hydrological networks, triggering profound eco-hydrological consequences.
Tianliang Jiang, Yanping Qu, Xuejun Zhang, Dandan Su, Yu Han, Ruixuan Zhao   +5 more
doaj   +1 more source

Climate and land management accelerate the Brazilian water cycle. [PDF]

Nat Commun, 2022
Chagas VBP, Chaffe PLB, Blöschl G.
europepmc   +1 more source

Comparative performance of twenty-three types of flat plate solar energy collectors [PDF]

, 1975
Report compares efficiencies of 23 solar collectors for four different purposes: operating a Rankine-cycle engine, heating or absorption air conditioning, heating hot water, and heating a swimming ...
Simon, F. F.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Remote sensing facilitates the exploration of algal bloom dynamics and its hydrometeorological drivers in tributary bays of the Three Gorges Reservoir

Science of Remote Sensing
Reservoir construction has led to frequent algal blooms in tributaries of backwater areas, threatening water quality, aquatic ecological safety, and public health.
Aiping Jiang, Dongsheng Wang, Tiantian Jin, Peng Li, Tao Xu, Di Zhang, Boran Zhu, Junqiang Lin, Qidong Peng   +8 more
doaj   +1 more source

Distinguishing Direct Human-Driven Effects on the Global Terrestrial Water Cycle. [PDF]

Earths Future, 2022
Kåresdotter E, Destouni G, Ghajarnia N, Lammers RB, Kalantari Z.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Identification of driving mechanisms of actual evapotranspiration in the Yiluo River Basin based on structural equation modeling

Ecological Processes
Background Actual evapotranspiration (ETa) is a crucial aspect of the hydrological cycle. It serves as a vital link between the soil–vegetation–atmosphere continuum.
Shu Xu, Tianling Qin, Jie Lu, Shanshan Liu, Jun Hou, Jianming Feng, Wei Li, Hanxiao Liu, Sintayehu A. Abebe   +8 more
doaj   +1 more source