Results 31 to 40 of about 3,075,262 (303)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Dynamics of oxygen evolution in a thermally stratified reservoir under climate warming

Scientific Reports
Dissolved oxygen (DO) is a key variable in water quality management of lakes and reservoirs. The prediction of DO dynamics is challenging due to interactions of ecological, biogeochemical, and physical processes strongly influenced by climate warming. We
Bing Ma, Fei Dong, Wenqi Peng, Xiaobo Liu, Aiping Huang   +4 more
doaj   +1 more source

Towards a global interpretation of dual nitrate isotopes in surface waters [PDF]

, 2019
Modern anthropogenic activities have significantly increased nitrate (NO3-) concentrations in surface waters. Stable isotopes (delta N-15 and delta O-18) in NO3- offer a tool to deconvolute some of the human-made changes in the nitrogen cycle.
Boeckx, Pascal, Gooddy, DC, Venkiteswaran, JJ   +2 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Dynamic monitoring of ecological security patterns in arid zone oases: a remote sensing-based ecological index evolution analysis

Scientific Reports
As vital biological hubs in delicate ecosystems, oasis in arid zones provide vital ecosystem services that include resource availability, biodiversity preservation, and temperature management.
Longlong Zhang, Jiaqi Zhai, Fan He, Xing Li, Tao Wang   +4 more
doaj   +1 more source

A Remote Sensing-Driven Dynamic Risk Assessment Model for Cyclical Glacial Lake Outbursts: A Case Study of Merzbacher Lake

Remote Sensing
The increasing threat of Glacial Lake Outburst Floods (GLOFs), intensified by climate change, underscores the urgency for developing advanced early warning systems. The near-annual, cyclical outbursts of Lake Merzbacher in the Tien Shan mountains present
Tianshi Feng, Wenlong Song, Xingdong Li, Yizhu Lu, Kaizheng Xiang, Shaobo Linghu, Hongjie Liu, Long Chen   +7 more
doaj   +1 more source

Can switching fuels save water? A life cycle quantification of freshwater consumption for Texas coal-and natural gas-fired electricity [PDF]

, 2012
Thermal electricity generation is a major consumer of freshwater for cooling, fuel extraction and air emissions controls, but the life cycle water impacts of different fossil fuel cycles are not well understood.
Beach, Fred C., Grubert, Emily A., Webber, Michael E.   +2 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Global water cycle [PDF]

The primary objective is to determine the scope and interactions of the global water cycle with all components of the Earth system and to understand how it stimulates and regulates changes on both global and regional scales.
Christy, John R., Fitzjarrald, Dan, Goodman, Steven J., Lapenta, Bill, Miller, Tim L., Robertson, Franklin R., Wang, Shouping   +6 more
core   +4 more sources

Analytical Model of Velocity Distribution and Penetration Characteristics in Water‐Level Fluctuation Zone With Vegetation

Water Resources Research
As a critical ecological transition zone between aquatic and terrestrial ecosystems, the water‐level fluctuation zone significantly influences flow structure through vegetation morphology.
An‐Qi Li, Xiao‐Bo Liu, Wei‐Jie Wang, Zhuo‐Wei Wang, Feng‐Jiao Li, Ming‐Yang Xu, Wei Huang   +6 more
doaj   +1 more source