Results 51 to 60 of about 3,075,262 (303)

Artificial Photosynthesis Would Unify the Electricity-Carbohydrate-Hydrogen Cycle for Sustainability [PDF]

, 2010
Sustainable development requires balanced integration of four basic human needs – air (O2/CO2), water, food, and energy. To solve key challenges, such as CO2 fixation, electricity storage, food production, transportation fuel production, water ...
Yi-Heng Percival Zhang
core   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Ecological water replenishment effects on groundwater recovery in the largest shallow groundwater depression cone of the North China Plain

Scientific Reports
The North China Plain is among the world’s most severely groundwater-overexploited regions. Since 2018, large-scale ecological water replenishment (EWR) has been applied, yet its long-term impacts on groundwater dynamics and efficient EWR strategies ...
Wen Lu, Chuiyu Lu, Yangwen Jia, Yong Zhao, Xin He, Qingyan Sun, Chu Wu, Wenjia Zhang, Zhenjiang Wu   +8 more
doaj   +1 more source

Interpretable machine learning workflow for estimating reference crop evapotranspiration in China's five major dry-wet regions using limited meteorological data

Agricultural Water Management
Accurate estimation of reference crop evapotranspiration (ET0) is crucial for improving water use efficiency and the design and operation of agricultural water management systems.
Ziyu Guan, Changhai Qin, Yong Zhao, Junlin Qu, Rong Liu, Yuan Liu, Wenxin Che, Tao Wang   +7 more
doaj   +1 more source

Synergistic Optimization of Water Resources Allocation Based on Energy Transition [PDF]

E3S Web of Conferences
Against the backdrop of global climate governance and the low-carbon energy transition, the cumulative impacts of traditional energy development on regional water resource systems are becoming increasingly prominent.
Xing Yuhan, Jia Ling, Lin Pengfei, Liu Danni, Zhu Shaoming, Liu Yishu   +5 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Changes in Runoff Volumes of Inland Terminal Lake: A Case Study of Lake Daihai

Earth and Space Science, 2021
The reduction of the runoff to lake has become a common phenomenon of the inland lakes in northwest China, and the quantitative calculation of the driving factors affecting the runoff change has always been a challenge in lake research.
Qianxun Wang, Xuekai Chen, Wenqi Peng, Xiaobo Liu, Fei Dong, Aiping Huang, Weihao Wang   +6 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source