Results 71 to 80 of about 3,075,262 (303)

Research on Instantaneous Sediment Concentration in Muddy Coastal Waters Under Extreme Weather Conditions

Journal of Marine Science and Engineering
This study addresses a fundamental limitation inherent in conventional sediment transport capacity formulas—their failure to accurately capture real-time fluctuations in suspended sediment concentration.
Qinghui Qi, Dong Xu, Youbin Ding
doaj   +1 more source

Storm Water and Contamination Control Efficiency Evaluation for Construction of a Neighborhood Project Using Low Impact Development

MATEC Web of Conferences, 2018
Urban flooding and water pollution are urgent problems to be solved in urban development. The improvement of urban drainage and water quality in urban construction using ecological measures is an important research task. Low impact development (LID) is a
Liu Bing, Xie Gang, Wang Yousheng, Yin Xiaolin, Zhang Xiaoming, Zhao Yang   +5 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Evaluating Leaf Water Potential of Maize Through Multi-Cultivar Dehydration Experiments and Segmentation Thresholding

Remote Sensing
Estimating leaf water potential (Ψleaf) is essential for understanding plant physiological processes’ response to drought. The estimation of Ψleaf based on different regression analysis methods with hyperspectral vegetation indices (VIs) has been proven ...
Shuanghui Zhao, Yanqun Zhang, Pancen Feng, Xinlong Hu, Yan Mo, Hao Li, Jiusheng Li   +6 more
doaj   +1 more source

Life cycle assessment of drinking water: comparing conventional water treatment, reverse osmosis and mineral water in glass and plastic bottles [PDF]

, 2016
This study evaluated the environmental impacts caused by drinking water consumption in Barcelona (Spain) using the Life Cycle Assessment (LCA) methodology. Five different scenarios were compared: 1) tap water from conventional drinking water treatment; 2)
Cadena, Erasmo, Ferrer Martí, Ivet, Garfi, Marianna, Sanchez Ramos, David   +3 more
core   +3 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Investigation on efficiency improvement of a Kalina cycle by sliding condensation pressure method [PDF]

, 2017
Conventional Kalina cycle-based geothermal power plants are designed with a fixed working point determined by the local maximum ambient temperature during the year.
Wang, Enhua, Yu, Zhibin, Zhang, Fujun
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

NDAWL-PINN: a new non-dimensionalization and multi-task learning approach for efficient training of physics-informed neural networks to solve the shallow water equations

Engineering Applications of Computational Fluid Mechanics
The exploration of deep learning methodologies has recently generated significant interest in the use of Physics-Informed Neural Networks (PINNs) to address complex physical problems governed by partial differential equations (PDEs).
Xin Qi, Dawei Zhang, Fan Wang, Wuxia Bi, Mingda Lu   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source