Results 81 to 90 of about 3,075,262 (303)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Quantifying anthropogenic impacts on water conservation and exploring enhancement pathways within a coupled nature-society framework

Journal of Hydrology: Regional Studies
Study regions: The Yellow River Water Conservation Area (YRWCA), an ecologically functional water source area of the Yellow River Basin, China. Study focus: This study developed a novel assessment framework based on the dualistic natural-societal water ...
Yaobing Sui, Cunwen Niu, Yangwen Jia, Xingyan Tan, Dongdong Wang, Xuanxuan Wang, Xiangling Sun   +6 more
doaj   +1 more source

Regional and global hydrology and water resources issues: The role of international and national programs [PDF]

, 2002
This paper presents an overview of water resources issues in the context of world population growth, climate change, and variability, and provides examples of how these issues affect local and regional water policy concerns.
Hogue, TS, Sorooshian, S, Whitaker, MPL
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Modelling of water balance and nitrogen cycle in vegetative filter strips [PDF]

, 2006
The retention of nutrients by 10-m-wide grass buffers and buffers under natural vegetation has been studied over 10 years in Jokioinen in southwestern Finland. The results have been compared with those from 70-m-long plots without buffers. Grass was sown
Granlund, Kirsti, Palojärvi, Ansa, Pietola, Liisa, Rankinen, Katri, Regina, Kristiina, Uusi-Kämppä, Jaana   +5 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Study on the motion characteristics of bedload sediment particles under different sediment transport intensities

River
Bedload studies at the particle scale may help grasp the essence of the problem. Existing studies suffer from short filming durations, limited data volume, and a narrow range of sediment transport intensity variations.
Chunjing Liu, Lingfeng Zhang, Yu Zhang, Xiaopeng Jiang, Fei Liu, Leilei Gu, Jing Lu   +6 more
doaj   +1 more source

Determination of UAV Flight Altitude and Time for Optimizing Variable-Rate Nitrogen Prescription Maps for Winter Wheat in the North China Plain

Agronomy
An unmanned aerial vehicle (UAV) multi-spectral system provides a monitoring platform to rapidly obtain crop spectral information that can reflect crop nitrogen status for the generation of dynamic variable-rate nitrogen (VRN). To improve the accuracy of
Minne Zhang, Weixia Zhao, Jiusheng Li
doaj   +1 more source

GCM simulations of the martian water cycle [PDF]

, 2003
Results from the Viking Orbiter Mars Atmospheric Water Detectors (MAWD) have long been the definitive data set for observations of the Martian water cycle (Farmer et al., 1977).
Bottger, H.M., Forget, F., Lewis, S.R., Read, P.L.   +3 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source