Results 31 to 40 of about 624,795 (265)
LandWetland ecosystems are essential to the global carbon cycle, and they contribute significantly to carbon storage and regulation. While existing studies have explored the individual effects of the water depth, vegetation, and soil properties on the soil ...
Yongkang Wang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Journal of Water and Land Development, 2018 The present work was designed to assess the contamination level in the coastal of Annaba, following the spectrophotometric determination of the level of some metallic elements (Fe, Cu, Pb, Zn, Ni and Cd) in the sediments along an increasing bathymetric ...
Ouali Naouel +3 more
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Seed Germination Indicates Adaptive Transgenerational Plasticity in a Submerged Macrophyte
Frontiers in Plant Science, 2018 Adaptive transgenerational plasticity is an important evolutionary strategy in plants. We investigated the resource allocation strategy in sexual reproduction and performed an in situ seed germination experiment of Potamogeton maackianus to reveal their ...
Hong Su +6 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Water Resources ResearchIn the absence of adequate observations on the off‐channel areas, flood models are typically trained and validated against stream water depths. This approach can be efficient for physics‐based models, which incorporate the underlying physical processes ...
Maryam Pakdehi, Ebrahim Ahmadisharaf
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Journal of Ecology and EnvironmentBackground: Koreoleptoxis globus is an endangered candidate species of snail in South Korean streams. This species primarily inhabits streams characterized by fast current velocities and coarse-particle streambed substrates.
Jin-Young Kim +4 more
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source