Results 61 to 70 of about 8,955,548 (305)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

SAR-based dynamic information retrieving of the Beijing-Tianjin-Hebei flood-inundation happened in July 2023, North China

Geomatics, Natural Hazards & Risk
Climate change-induced rainfalls have elevated the likelihood of flood occurrences, disrupting severely the normal functioning of people. Especially in the geographically unique Beijing-Tianjin-Hebei (BTH) plain in north China, an unanticipated sudden ...
Zhijun Jiao, Zhimei Zhang, Lixin Wu
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Development of A Rigorous Model for Bathymetric Mapping from Multispectral Satellite-Images

Remote Sensing, 2022
Models for bathymetry retrieval from multispectral images have not considered the errors caused by tidal fluctuation. A rigorous bathymetric model that considers the variation in tide height time series, including the tide height calculation and ...
Jiasheng Xu, Guoqing Zhou, Sikai Su, Qiaobo Cao, Zhou Tian   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Determinação do perfil radial de aspersores a partir de ensaios de distribuição de água em sistemas autopropelidos de irrigação Determining sprinkler patterns from water distribution tests of traveller irrigation systems

Engenharia Agrícola, 2010
Este trabalho apresenta uma rotina computacional, em Visual Basic 6, para determinar o perfil radial de aspersores, mediante ensaios de equipamentos autopropelidos de irrigação.
Giuliani do Prado, Alberto Colombo
doaj   +1 more source

Water Depth Influences the Head Depth of Competitive Racing Starts

International Journal of Aquatic Research and Education, 2011
Recent research suggests that swimmers perform deeper starts in deeper water (Blitvich, McElroy, Blanksby, Clothier, & Pearson, 2000; Cornett, White, Wright, Willmott, & Stager, 2011). To provide additional information relevant to the depth adjustments swimmers make as a function of water depth and the validity of values reported in prior literature ...
Andrew C. Cornett, Josh C. White, Brian V. Wright, Sandy Willmott, Joel M. Stager   +4 more
openaire   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The Effect of the External Counter Rotating for the Water Flow Velocity Profile of Twin Propeller System

Journal of Applied Science and Engineering
The posture of water flow velocity generated by the rotation of the ship’s propeller needs to be studied to see the performance of the propeller and the potential for scouring that the seabed can cause.
Abdul Kadir, Istadi, Agus Subagio, Iskendar, Waluyo, Dewi Kartikasari, Hendra Palebangan, Siti Sadiah, Sutriyanto Himawan, Putri Virliani, Y.F. Kusuma, Dwi Wahyudi, Erlangga Satria Aidil Putra, Fadila Norasarin Eritha   +13 more
doaj   +1 more source