Results 201 to 210 of about 353,290 (260)

Magnetic and magnetotelluric data integration to determine the origin of Siwa Oasis Lakes, Western Desert, Egypt. [PDF]

Sci Rep
Aldeep M, Soliman M, Mesbah HSA, Gaweish WR, Ali AM, Meqbel N, Zaher MA.   +6 more
europepmc   +1 more source

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Reference genome bias in light of species-specific chromosomal reorganization and translocations. [PDF]

Genome Biol
Maurstad MF, Hoff SNK, Cerca J, Ravinet M, Bradbury I, Jakobsen KS, Præbel K, Jentoft S.   +7 more
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Rapid genome modifications including chromosomal fusions and large-scale inversions are key features in Arctic codfish species. [PDF]

Genome Biol
Hoff SNK, Maurstad MF, Tørresen OK, Araya RA, Berg PR, Præbel K, Jakobsen KS, Jentoft S.   +7 more
europepmc   +1 more source

Design and Optimization of Full‐Stokes Hyperspectro‐Polarimetric Encoding Metasurfaces Based on Conditional Multi‐Task Deep Learning

Advanced Science, EarlyView.
A conditional multi‐task deep learning framework is developed for designing and optimizing Full‐Stokes Hyperspectro‐Polarimetric Encoding Metasurfaces (FHPEMs). This framework achieves joint spectro‐polarimetric learning and unified forward–inverse design.
Chenjie Gong, Haodong Shi, Qi Wang, Yingchao Li, Hongyu Sun, Jiayu Wang, Guanlin Li, Jian Zhang, Qiang Fu, Huilin Jiang   +9 more
wiley   +1 more source

Sensitivity analysis of VG model parameters for infiltration in undisturbed loess under ponding conditions using the HYDRUS-1D model. [PDF]

Sci Rep
Wang X, Huang Z, Qin H, Dai F.
europepmc   +1 more source

Deciphering the Evolution Pattern of Structural Variations Overlapped With Repetitive Sequence During Cattle Evolution

Advanced Science, EarlyView.
The authors complement bovine pan‐SV with massive novel structural variations (SVs) identified through long‐read sequencing of 83 globally distributed cattle breeds. Repetitive sequence‐mediated SVs (rep‐SV) exhibit distinct dynamic patterns throughout cattle sub‐speciation and/or domestication processes, including uneven distribution between chr‐X and
Zhifan Guo, Jinxiu Li, Adeniyi C. Adeola, Xueyan Jiang, Juntao Ma, Jian Xiao, Dexiang Hu, Kaixing Qu, Haihong Wu, Junren Chen, Zhanxing He, Tingting Yin, Ali Esmailizadeh, Jing Luo, Olivier Hanotte, Ya‐Ping Zhang, Yan Li   +16 more
wiley   +1 more source

Crustal constraints on the surface expression of mantle upwelling in a back-arc passive margin setting. [PDF]

Sci Rep
Hwang JY, Chang SJ, Sohn YJ, Kim KH.
europepmc   +1 more source