Results 21 to 30 of about 215,408 (268)

Some properties of Guyon's method for drain spacing determination on the marshy gley soil [PDF]

open access: yesJournal of Agricultural Sciences (Belgrade), 2005
The aim of this work is to show out some properties of Guyon's method for drain spacing determination in unsteady state of flow. The analysis has been carried out in the marshy gley soil of the experimental field with drain spacing of 10 m, 20 m and 30 m.
Đurović Nevenka, Stričević Ružica
doaj   +1 more source

Quantum Neural Networks Approach for Water Discharge Forecast

open access: yesApplied Sciences
Predicting the river discharge is essential for preparing effective measures against flood hazards or managing hydrological droughts. Despite mathematical modeling advancements, most algorithms have failed to capture the extreme values (especially the ...
Liu Zhen, Alina Bărbulescu
doaj   +1 more source

Hydrological and hydrochemical regime of the main rivers of the Kabardino-Balkar high-mountain state reserve under conditions of modern climate change

open access: yesНаука. Инновации. Технологии
In recent decades, there has been an increase in water resources and a change in the intra-annual distribution of runoff in many areas of the European part of Russia.
I. I. Kuchmenova
doaj   +1 more source

MODIS Imagery Based Water Content Forecasting Methodology for Mountain Rivers in Central Asia

open access: yesCentral Asian Journal of Water Research, 2020
The article investigates the possibility of using snow cover satellite data for short-term hydrological forecasting for Central Asian rivers with high-altitude catchments.
J.B. Niyazov   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Water Use in the Economies of the Regions of the Lower Dnipro Sub-Basin Before and After the Destruction of the Kakhovka Reservoir

open access: yesСтатистика України
To fulfil the goal, the methodological approach to the economic analysis of regions belonging of the river sub-basin – the Lower Dnipro sub-basin, was refined so as to base on computing the economic indicators reflecting the level of economic development
O. I. Nykyforuk   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

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