BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
Water distribution Network Management in Emergency Conditions
Procedia Engineering, 2015 Abstract The management of Water Distribution Systems (WDS) is strictly connected to the emergency conditions. Critical events can cause the inefficiency of the network, so the head in some nodes could be inadequate to guarantee the service for the users.
FIORINI MOROSINI, Attilio +3 more
openaire +1 more source
EVALUASI DAN PENGEMBANGAN JARINGAN DISTRIBUSI AIR BERSIH DI KECAMATAN TUREN KABUPATEN MALANG [PDF]
Clean water is a basic need for society, but the distribution of clean water in Turen District, Malang Regency still faces several problems. This research aims to evaluate the condition of the clean water distribution network and propose development ...
Olviyani, Mustikarina
core
Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon +12 more
wiley +1 more source
Energy saving policy in water distribution networks
Renewable Energy and Power Quality Journal, 2009 In the last years, issues concerning water saving in water distribution systems have paid interest through an integrated policy aiming at reducing leakage by means of pressure control. Hence, in water distribution systems Pressure Reducing Valves (PRVs) are often used to prevent the downstream hydraulic grade from exceeding a set value.
GIUGNI, MAURIZIO +2 more
openaire +2 more sources
Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin +2 more
wiley +1 more source
A risk-based soft sensor for failure rate monitoring in water distribution network via adaptive neuro-fuzzy interference systems. [PDF]
Sci Rep, 2023 Gheibi M +9 more
europepmc +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Combined application of EPANET and empirical model for possible formation of trihalomethanes in water distribution network of Chattogram city to identify potential carcinogenic health risk zone. [PDF]
Heliyon, 2023 Zuthi MFR +6 more
europepmc +1 more source
Demand Pattern Calibration in Water Distribution Networks
Procedia Engineering, 2014 Water distribution network models are widely used by water companies. Consumer demands are one of the main uncertainties in these models, but their calibration is not feasible due to the low number of sensors available in most real networks. However, the behaviour of these individual demands can be also calibrated if some a priori information is ...
Sanz Estapé, Gerard +1 more
openaire +2 more sources