Results 41 to 50 of about 3,013,990 (285)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Draining the Water Hole: Mitigating Social Engineering Attacks with CyberTWEAK

open access: yes, 2019
Cyber adversaries have increasingly leveraged social engineering attacks to breach large organizations and threaten the well-being of today's online users.
Bittleston, Daniel   +7 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

SPH Simulation of Interior and Exterior Flow Field Characteristics of Porous Media [PDF]

open access: yes, 2020
At the present time, one of the most relevant challenges in marine and ocean engineering and practice is the development of a mathematical modeling that can accurately replicate the interaction of water waves with porous coastal structures. Over the last
Gui, Qinqin   +2 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The development of water services and their interaction with water resources in European and Brazilian cities [PDF]

open access: yesHydrology and Earth System Sciences, 2008
The extension and complexity of large cities creates "urban water" and a related issue: public water services, including public water supply, sewage collection and treatment, and storm water control, had previously become a policy sector ...
B. Barraqué   +2 more
doaj  

Alaskan water resources: Selected abstracts, 1974 [PDF]

open access: yes, 1977
Compiled and Edited by Charles Hartman and Sheila. FinchAs one of the 51 Water Resources Research Institutes administered under the Water Resources Research Act of 1964, IWR receives a semimonthly journal entitled Selected Water Resources Abstracts.
Finch, Sheila, Hartman, Charles
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Recent progress in highly effective electrocoagulation-coupled systems for advanced wastewater treatment

open access: yesiScience
Summary: Electrocoagulation (EC) has been a well-known technology for wastewater treatment over the past centuries, owing to its straightforward equipment requirements and highly effective contaminant removal efficiency. This literature review emphasizes
Thi Kim Cuong Phu   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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