Results 41 to 50 of about 3,040,620 (306)

Engineering characteristics and control technology of soft rock deterioration effect based on water inducement

open access: yesMeikuang Anquan, 2021
In order to solve the technical problem of soft rock engineering deterioration with expansive water-rich in Inner Mongolia Shanghaimiao Mining Co., Ltd., the experiment of the influence of water content on the mechanical properties of rock was carried ...
LYU Yuguang, LYU Wenbin, XIAO Qinghua, WANG Yongbao, XIA Yujun, ZHANG Yongqiang, WU Su
doaj   +1 more source

Draining the Water Hole: Mitigating Social Engineering Attacks with CyberTWEAK

open access: yes, 2019
Cyber adversaries have increasingly leveraged social engineering attacks to breach large organizations and threaten the well-being of today's online users.
Bittleston, Daniel   +7 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Values in Water [PDF]

open access: yes, 2018
Inaugural speech spoken in acceptance of the chair ‘Ethics of water engineering’ at the Faculty of Technology, Policy and Management of Delft University of Technology on 16 November ...
Doorn, Neelke
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

The development of water services and their interaction with water resources in European and Brazilian cities [PDF]

open access: yesHydrology and Earth System Sciences, 2008
The extension and complexity of large cities creates "urban water" and a related issue: public water services, including public water supply, sewage collection and treatment, and storm water control, had previously become a policy sector ...
B. Barraqué   +2 more
doaj  

SPH Simulation of Interior and Exterior Flow Field Characteristics of Porous Media [PDF]

open access: yes, 2020
At the present time, one of the most relevant challenges in marine and ocean engineering and practice is the development of a mathematical modeling that can accurately replicate the interaction of water waves with porous coastal structures. Over the last
Gui, Qinqin   +2 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Recent progress in highly effective electrocoagulation-coupled systems for advanced wastewater treatment

open access: yesiScience
Summary: Electrocoagulation (EC) has been a well-known technology for wastewater treatment over the past centuries, owing to its straightforward equipment requirements and highly effective contaminant removal efficiency. This literature review emphasizes
Thi Kim Cuong Phu   +2 more
doaj   +1 more source

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