Results 61 to 70 of about 76,783 (257)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Multilevel Regression Analysis for Measuring Risk Reduction in Water Treatment Facilities Systems in Tanzania: An Engineering Perspective

, 2011
Water treatment facilities in Tanzania face risks that can impact their functionality and efficiency. Multilevel regression analysis was employed to assess the effectiveness of various risk mitigation measures across different levels of the system.
Chituco, Mwamalijira, Kibogo, Simiyu, Maganga, Kamanda   +2 more
openaire   +2 more sources

Chemical and Radiochemical Constituents in Water from Wells in the Vicinity of the Naval Reactors Facility, Idaho National Engineering and Environmental Laboratory, Idaho, 1997-98 [PDF]

Open-File Report, 2000
The US Geological Survey, in response to a request from the U.S Department of Energy's Pittsburgh Naval Reactors Office, Idaho Branch Office, sampled water from 13 wells during 1997-98 as part of a long-term project to monitor water quality of the Snake River Plain aquifer in the vicinity of the Naval Reactors Facility, Idaho National Engineering and ...
Roy C. Bartholomay, LeRoy L. Knobel, Betty J. Tucker, Brian V. Twining   +3 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Technical challenges and development prospects for capacity expansion and production ramp-up of depleted-reservoir-type gas storage facilities

You-qi chuyun
ObjectiveTo address the growing gap between China’s rapidly increasing demand for natural gas peak-shaving and the limited effective working gas volume of underground gas storage facilities, this study reviews the development of depleted-reservoir-type ...
Huohai YANG, Jia DENG, Jun HU, Xiaojian SU, Feng XU, Yuxia SHI, Siyuan ZHANG, Renze LI   +7 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Graphene Oxide Incorporated Forward Osmosis Membranes With Enhanced Desalination Performance and Chlorine Resistance

Frontiers in Chemistry, 2020
In this work, grapheme oxide (GO) nano-sheets were synthesized and dispersed in the aqueous phase for the interfacial polymerization (IP) process to develop a new type of thin-film composite (TFC) membranes for forward osmosis (FO) applications.
Zhanguo Li, Yi Wang, Yi Wang, Mengwei Han, Dayong Wang, Shitong Han, Zequn Liu, Ningyu Zhou, Ran Shang, Chaoxin Xie   +9 more
doaj   +1 more source

Facile one-pot scalable strategy to engineer biocidal silver nanocluster assembly on thiolated PVDF membranes for water purification

RSC Advances, 2016
Biofouling, due to bacterial growth and colonization, is a significant obstacle in water treatment that severely affects the membrane performance.
Maya Sharma, Nagarajan Padmavathy, Sanjay Remanan, Giridhar Madras, Suryasarathi Bose   +4 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Energy Savings and Sustainability Opportunities at US Army Corps of Engineers Facilities: A Guide to Identify, Prioritize, and Estimate Projects at Complexes That Have Not Conducted a Facility-Level Energy and Water Evaluation [PDF]

, 2012
Abstract : Executive Order (EO) 13514, Federal Leadership in Environmental, Energy, and Economic Performance, expanded on the energy re-duction and environmental performance requirements of Executive Order 13423, Strengthening Federal Environmental, Energy, and Transportation Management, by adding sustainability requirements and performance planning ...
Laura Curvey, David M. Underwood
openaire   +1 more source