Results 31 to 40 of about 408,947 (215)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Water quality variables and emerging environmental contaminant in water for human consumption in Rio Grande do Sul, Brazil

Environmental Challenges, 2021
This research aimed to qualify and quantify physical, chemical, microbiological and emerging environmental contaminants, pharmaceuticals and pesticides in spring waters, which are used for human consumption under different land use and occupation ...
Débora Seben, Marcos Toebe, Arci Dirceu Wastowski, Keli Hofstätter, Fernanda Volpatto, Renato Zanella, Osmar Damian Prestes, Jaqueline Ineu Golombieski   +7 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Analysis of the Average Annual Consumption of Water in the Hospitals of Extremadura (Spain)

Energies, 2017
The aim of this paper is to quantity the annual average consumption of water in 13 public hospitals in Extremadura (Spain). An analytical study in order to reduce water demand was conducted from 2010 to 2014 in the above-mentioned hospitals.
Justo Garcia-Sanz-Calcedo, Fernando Lopez-Rodriguez, Talal Yusaf, Awf Al-Kassir   +3 more
doaj   +1 more source

Toxic chromium in water and the effects on the human body: a systematic review

Journal of Water and Health, 2023
Both in developed and developing countries, there is a growing concern about the dangerous hexavalent chromium, in the consumption of drinking water. Hexavalent chromium is recognized to have a negative impact on the human body, both in the short and ...
Maria-Nefeli Georgaki, Marianna Charalambous   +1 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Calidad bacteriológica del agua de consumo humano de la zona urbana y rural del municipio de Guatavita, Cundinamarca, Colombia Bacteriological quality of the water for human consumption in urban and rural areas of the municipality of Guatavita, Cundinamarca, Colombia

Revista Cubana de Higiene y Epidemiología, 2012
Guatavita es un municipio ubicado en el Departamento de Cundinamarca, Colombia. Posee recursos hídricos como ríos, quebradas, lagunas y nacimientos, que representan un alto porcentaje del agua con que se abastece.
Sara Lilia Ávila de Navia, Sandra Mónica Estupiñán Torres   +1 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

QUALITATIVE ANALYSIS OF THE SHALLOW UNDERGROUND WATERS OF BENEVIDES, PARÁ, BASED ON MULTIVARIATE STATISTICAL METHODS [PDF]

Química Nova
Groundwater is considered an important source of water aid for human consumption. However, this water can be contaminated by impurities, such contamination spots that might reach the water tables.
Neuton T. Vasconcelos Junior, Paulo P. Araújo, Kelson C. F. Faial, Bruno S. Carneiro   +3 more
doaj   +1 more source