Results 41 to 50 of about 28,076 (308)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Water Framework Directive: A New Directive for a Changing Social, Political and Economic European Framework [PDF]
European Planning Studies, 2003 This article examines the intricate process of developing the European Union's Water Framework Directive. It sees the Directive as a response to recent economic, political and social changes related to water management, including the shift from government to governance, the liberalization of water markets and the emergence of a new set of institutions,
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Water Framework Directive observatory: an assessment of the WFD implementation process in Spain [PDF]
, 2010 This paper deals primarily with the assessment of the Water Framework Directive (WFD) implementation in the Iberian basins. This assessment has been carried out in an innovative way by the Observatory of the Water Framework Directive known with the ...
Ferrer, Garciela, La Roca, Francesc
core
Impact of the European Water framework directive on knowledge of biodiversity [PDF]
Sciences, Eaux & Territoires, 2011 The European Water framework directive requires observation and monitoring of certain biological communities to assess the ecological status of aquatic environments. How does the WFD contribute to knowledge and evaluation of aquatic biodiversity?
ARGILLIER, Christine +1 more
doaj
Oceanological and Hydrobiological Studies, 2023 Lakes İznik and Manyas located in Türkiye are important biodiversity resources in the Palearctic region. No studies to date have explored the ecological statuses of these lakes together with their water quality based on biotic indices utilizing benthic ...
Mercan Deniz, Arslan Naime
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Evaluation of the ecological status of natural lakes in Spain: overview of the works performed by the cedex for the implementation of the Water Framework Directive [PDF]
, 2010 This paper presents an overview of the work that has been done by the CEDEX for the implementation in Spain of the Water Framework Directive on water bodies belonging to the lake category.
Camacho, Antonio +2 more
core
Acta Universitatis Carolinae Geographica, 2017 In this study, a comprehensive 30-year (1984–2016) water quality parameter database for Lake Koronia – one of the most important Ramsar wetlands of Greece – was compiled from Landsat imagery.
Triantafyllia-Maria Perivolioti +4 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source