Results 171 to 180 of about 2,752,436 (316)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Community-based nearshore wave and water level monitoring in Nunavut, Arctic Canada 2021-2023. [PDF]

Sci Data
Didier D, Zouaghi F, Coulombe S, Noah T, Bertrand EM, Stolle J, Jourdain-Bonneau C, Baudry J, Binette S, Nicot P, Akana R, Noël B, Boisson A, Dubuc D, Berry B, Ferland G, Lafosse L, Omonigbehin O, Stancu C, Guay CA, Said HB, White P, Heras Duran A, Audlaluk Watsko L, Qaapik J, Walch DMR, Hallé D, Parrott C, Spence J, Hamilton AK, Quénet Y, Gagnon S, Bélanger S, Bouchard F, Kurylyk B, Chaillou G, Dumont D, Myers P, Eamer J, Normandeau A, Bhatia M.   +40 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Improving coastal water level estimation by merging nadir-only satellite altimetry data into a hydrodynamic model. [PDF]

Environ Monit Assess
Bhuiyan SA, De Lima AS, Miesse T, Henke M, Ferreira C, Maggioni V.   +5 more
europepmc   +1 more source

Working together for more equitable water sharing solutions [PDF]

A new video from the CGIAR Initiatives on Asian Mega-Deltas and Aquatic Foods documents work to support Cambodia to delegate the management of water, land, agriculture, fisheries, and the environment to the district level.
WorldFish, International Water Management Institute   +1 more
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Development of Real-Time Water-Level Monitoring System for Agriculture. [PDF]

Sensors (Basel)
Borankulova G, Altybayev G, Tungatarova A, Yeraliyeva B, Dulatbayeva S, Murzakhmetov A, Bekbolatov S.   +6 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Penetration explosion damage and discharge of high arch dam with high reservoir water level. [PDF]

Sci Rep
Wu L, Wu A, Yu C, Huang R, Zhou J.
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source