Results 61 to 70 of about 1,484,040 (218)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Enhancing the quality of pear candies via jaggery‐based osmotic dehydration: Optimization and analysis

Future Postharvest and Food
Pear (Pyrus pyrifolia) is a healthy fruit; however, its availability is limited in certain seasons due to short shelf life. To overcome this limitation, a cost‐effective dehydration‐based preservation involving osmotic dehydration process with jaggery as
Gurpreet Dhillion, Amardeep Kour, Navjot Gupta, Padma Nath Atreya   +3 more
doaj   +1 more source

Factors affecting the mass transfer kinetics of osmotically dehydrated chayote (Sechium edule (Jacq.) Sw.)

Notulae Botanicae Horti Agrobotanici Cluj-Napoca
The aim of this study was to apply osmotic dehydration (OD) to produce minimally processed chayote (Sechium edule (Jacq.) Swartz) slices. Thus, the effect of osmotic solution concentration, temperature, processing time, and vacuum pulse application on ...
Karina HUERTA-VERA, Adriana CONTRERAS-OLIVA, Ma. de Lourdes ARÉVALO-GALARZA, Enrique FLORES-ANDRADE, Ma. Bernardita PÉREZ-GAGO, Diana P. USCANGA-SOSA   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

ABA-induced active stomatal closure in bulb scales of Lanzhou lily

Plant Signaling & Behavior
Abscisic acid (ABA) mediated stomatal closure is a highly effective mode of active stomatal regulation under drought stress. Previous studies on stomatal regulation have primarily focused on the leaves of vascular plants, while research on the stomatal ...
Lei Gong, Hai-Qing Liu, Ye Hua, Ya-Yun Zhang, Md. Mahadi Hasan   +4 more
doaj   +1 more source

Detecting Water Loss Sink Points in Shallow Flooded Agricultural Environments Using a Visual Technique Based on Infrared Thermography: Laboratory Testing

Agriculture
This study presents a new visual-based method that uses a thermal tracer and infrared thermography to detect sink points in shallow flooded areas. Laboratory experiments were conducted in a 2 × 2 m2 soil flume where different scenarios with varying sink ...
Soheil Zehsaz, João L. M. P. de Lima, M. Isabel P. de Lima   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mapping Flood Hazard Across Mainland China Through a Physics‐Based Global Flood Model With Embedded Reservoir Operation Scheme

Journal of Flood Risk Management
China has complex topography, diverse flood mechanisms, and high population exposure, making it highly vulnerable to flooding, highlighting the need for robust national‐scale hazard assessments to identify flood‐prone regions.
Jayesh Parmar, Subhankar Karmakar, Cheng Zhang, Yuexiao Liu, Slobodan P. Simonovic   +4 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source