Results 71 to 80 of about 1,190,304 (309)

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Identifying uncertainty guidelines for supporting policy making in water management illustrated for Upper Guadiana and Rhine Basins [PDF]

, 2010
In recent years, guidelines have been developed for supporting water managers in dealing with uncertainty in integrated water resources management (IWRM).
Lamers, M.A.J., Lamers, M., Refsgaard, J.C., Poolman, M.I., Warmink, J.J., Mysiak, J., van der Keur, P., Zorilla, P., Henriksen, H.J., Mysiak, J, Isendahl, N, Raadgever, G.T., Brugnach, M., van der Keur, P, Poolman, M, Poolman, M., Keur, P., van der, De Wulf, A., Zorilla, P, Dewulf, A., Isendahl, N., DeWulf, A, Brugnach, M   +22 more
core   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Towards integrated water resources management

, 2015
With input from 56,000 weather stations, the International Water Management Institute (IWMI) World Water and Climate Atlas gives agricultural planners rapid access to the best available data on climate, and moisture availability for agriculture.
International Water Management Institute (IWMI)
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Opportunities for private sector participation in agricultural water development and management

, 2014
Irrigation management / Private sector / Public sector / Public policy / Private investment / Participatory management / Privatization / Financing / Farmers / Households / Water harvesting / Africa South of ...
Penning de Vries, Frits, Inocencio, Arlene, Inocencio, Arlene B., Sally, Hilmy, Penning de Vries, Frits W.T.   +4 more
core   +1 more source

Spatial environmental classification of Lake Qarun in terms of water quality and morphology

Water Science
Lake Qarun, one of Egypt’s most important inland lakes, supports fisheries, tourism, and recreation but has undergone severe environmental deterioration over the past four decades due to agronomic, economic, and anthropogenic pressures.
Yousra Ahmed Fouad El Degwee, Emad Fawzi Mostafa, Eid Hosny Ashour, Mohamed Sherif Saad Shehata   +3 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Reduccion de la pobreza por medio de la gestion integrada de las aguas subteraneas y superficiales. In SpanishReducing poverty through integrated management of groundwater and surface water

, 2014
The full poverty-fighting potential of existing irrigation schemes is not being realized?largely because of inequitable water distribution and unsustainable land and water management practices.
Global Water Partnership, International Water Management Institute   +1 more
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Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

International Water Management Institute (IWMI): Financial Statements for the Years ended December 31, 2009 and 2008 and Auditor's Report

, 2010
International Water Management Institute (IWMI) financial statements for the years ended December 31, 2009 and 2008 and auditor's report by Ernst & Young, Colombo, Sri ...
International Water Management Institute
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