Optimized iCIEF Fractionation Enables Deep Profiling of Antibody Drug Conjugate Charge Heterogeneity
This study developed and optimized an iCIEF fractionation method to characterize ADC charge variants. The optimized approach enabled stable separation, identification of major PTMs, and drug‐load distributions across light and heavy chains. ABSTRACT Antibody drug conjugates (ADCs) are a novel class of therapeutic drugs that combine selectivity of an ...
Eunju Jang +2 more
wiley +1 more source
Exploring food spoilage: an inquiry-based laboratory for food microbiology education. [PDF]
Mangieri N +4 more
europepmc +1 more source
Abstract Objective The olive oil–based Mediterranean ketogenic diet (MedKD) may support patients with drug‐resistant epilepsy (DRE) or neurometabolic disorders by integrating ketogenic therapy with the cardiometabolic and neuroprotective advantages of the Mediterranean diet.
Sofia Zouganeli +8 more
wiley +1 more source
Eco-Microbiology: A Frugal-Circular Framework for Biosafe, Low-Cost Practical Microbiology in Secondary Education. [PDF]
Amorim L +4 more
europepmc +1 more source
Integrated study on the occurrence and genomic features of <i>Escherichia albertii</i> in environmental water and raccoons in Japan. [PDF]
Hinenoya A +5 more
europepmc +1 more source
Retraction Note: The effects of electrochemical, acoustic and superadditive pulsed discharge technologies on quality characteristics of various types of water. [PDF]
Oboturova N +10 more
europepmc +1 more source
Non-O157 shiga toxin-producing Escherichia coli (STEC) in Africa: a one health systematic review and meta-analysis of prevalence, antimicrobial resistance, and clinical outcomes. [PDF]
Akinduti PA +5 more
europepmc +1 more source
Complete genome sequence of <i>Bacillus velezensis</i> DDW3, an endophyte isolated from the leaves of <i>Matricaria chamomilla</i>. [PDF]
Du Y +6 more
europepmc +1 more source
<i>Legionella stuttgartensis</i> sp. nov. and <i>Legionella nigrisilvae</i> sp. nov., two new species isolated from a re-cooling plant and from a drinking water house installation in southern Germany. [PDF]
Rios Galicia B +5 more
europepmc +1 more source

