Results 91 to 100 of about 1,292,283 (312)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Arsenic(III) remediation from contaminated water by oxidation and Fe/Al co-precipitation [PDF]

, 2011
Battery grade γ-MnO2 powder was investigated as an oxidant and an adsorbent in combination with Fe/Al coagulants for removal of arsenic from contaminated water. Simultaneous oxidation of As(III) and removal by coprecipitation/adsorption (one step process)
Issa, T.B., Singh, P., Zhang, W.
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Computational Characterization of Single-Electron Transfer Steps in Water Oxidation

Inorganics, 2019
The presence of single-electron transfer (SET) steps in water oxidation processes catalyzed by first-row transition metal complexes has been recently recognized, but the computational characterization of this type of process is not trivial.
Adiran de Aguirre, Ignacio Funes-Ardoiz, Feliu Maseras   +2 more
doaj   +1 more source

A simple, novel method for preparing an effective water oxidation catalyst [PDF]

, 2010
A novel oxygen catalyst is prepared via the photodeposition of ruthnium (IV) oxide on a titania photocatalyst derived from a perruthenate ...
Amama, Duonghong, Jacobs, Kato, Kato, Kato, Kawai, Kim, Kim, Lin, McMurray, Mills, Mills, Mills, Mills, Minero, Nishimura, Sato, Sayama, Tak, Tanaka, Yamashita   +21 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Selective removal of organics for water reclamation [PDF]

Electrooxidation is a means of removing organic solutes directly from waste waters without the use of chemical expendables. The feasibility of the concept for oxidation of organic impurities common to urine, shower waters and space habitat humidity ...
Hitchens, G. Duncan, Kaba, Lamine, Murphy, Oliver J., Verostko, Charles E.   +3 more
core   +1 more source

Origin and evolution of water oxidation before the last common ancestor of the Cyanobacteria [PDF]

, 2015
Photosystem II, the water oxidizing enzyme, altered the course of evolution by filling the atmosphere with oxygen. Here, we reconstruct the origin and evolution of water oxidation at an unprecedented level of detail by studying the phylogeny of all D1 ...
A. William Rutherford, Anisimova, Arato, Arnold, Bader, Beanland, Blankenship, Campbell, Cardona, Cardona, Chu, Chu, Clausen, Cox, Criscuolo, Cser, Dagan, Dau, Debus, Debus, Deusch, Diner, Dismukes, Erickson, Ferreira, Fine, Flannery, Gan, Gan, Giorgi, Gould, Gouy, Guindon, Gupta, Guskov, Hasegawa, Hillier, Hoganson, Hohmann-Marriott, Huson, Ishikita, Ishikita, James W. Murray, Jia, Johnson, Kiss, Klimov, Kopp, Koyama, Kulkarni, Kuroda, Lambreva, Larom, Larsson, Lartillot, Lee, Lidholm, Linke, Loll, Lyons, Marin, Merry, Metz, Michel, Michel, Mimuro, Muh, Mulo, Mulo, Murray, Murray, Nakamura, Nitschke, Nixon, Nixon, Nixon, Ochoa de Alda, Oettmeier, Ogami, Park, Petrouleas, Qian, Rappaport, Rasmussen, Raymond, Rippka, Robinson, Rodriguez-Ezpeleta, Roose, Rutherford, Rutherford, Saito, Sauer, Saw, Sedoud, Service, Shevela, Shi, Shih, Sicora, Sicora, Siegbahn, Sievers, Sugiura, Sugiura, Sugiura, Sugiura, Summerfield, Tanai Cardona, Tichy, Toepel, Turner, Ulas, Umena, Vass, Vassiliev, Vermaas, Vermaas, Vermaas, Vinyard, Waldbauer, Wegener, Yoon, Zehr, Zhang, Zhang, Zimmermann   +126 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source