Results 51 to 60 of about 1,280,375 (291)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Nanomaterials, 2018 Carbon nitride materials with graphitic to polymeric structures (gCNH) were investigated as catalyst supports for the proton exchange membrane (PEM) water electrolyzers using IrO2 nanoparticles as oxygen evolution electrocatalyst.
Ana Belen Jorge +5 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Inorganics, 2019 Designing catalysts for water oxidation (WOCs) that operate at low overpotentials plays an important role in developing sustainable energy conversion schemes.
Nitish Govindarajan, Evert Jan Meijer
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
CHIMIA, 2021 Artificial water splitting is a promising technology that allows the storage of renewable energy in the form of energy-rich compounds. This mini-review showcases how theoretical studies contribute to the under-standing of existing water oxidation ...
Mauro Schilling +2 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Dynamic Potential-Ph Diagrams Application to Electrocatalysts for Water Oxidation [PDF]
, 2011 The construction and use of "dynamic potential-pH diagrams" (DPPDs), that are intended to extend the usefulness of thermodynamic Pourbaix diagrams to include kinetic considerations is described.
Bard, Allen J. +4 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
AD–OX: A sequential oxidative process for water treatment— Adsorption and batch CWAO regeneration of activated carbon [PDF]
, 2009 A sequential process for water treatment involving usual adsorption on activated carbon (AC) followed by wet air catalytic oxidation of the adsorbed pollutants has been carried out in a fixed bed reactor with a mixture of two model pollutants.
Creanga-Manole, Carmen +3 more
core +2 more sources