Results 131 to 140 of about 2,299,853 (287)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Use of jet devices for water supply and water removal

open access: yesRUDN Journal of Engineering Research, 2010
Is considered use of jet devices for water supply and water removal. Features and advantages of vortical jet hidroelevetor and prospects of their use for needs of water supply and water removal are presented.
Z Iztileuovich Мinarbekov
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mechanistic Insights into NDMA Adsorption onto Selected Pollutants and Their Removal via Direct Rapid Sand Filtration and After Enhanced Coagulation

open access: yesMolecules
N-nitroso dimethylamine (NDMA), a common nitrogen disinfection by-product and carcinogen, can be removed using rapid sand filtration (RSF) after coagulation; however, its removal mechanism has not been extensively studied.
Olubunmi M. Olukowi   +3 more
doaj   +1 more source

Evaluation of Packed Towers for Removing Volatile Organics from Surface Waters [PDF]

open access: yes, 1986
This study analyzes the potential of packed tower aeration as a remedial treatment process for the removal of trace organics on either an acute or chronic basis. Both pilot-scale installations of the packed tower process were reviewed. Included are basic
Moore, James W.
core   +2 more sources

Removing Fluoride From Water?

open access: yesJAMA Health Forum
This Viewpoint discusses the importance of continuing community water fluoridation in the US.
Brett Kessler, Scott D. Smith
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Removal of Cyanides from Gadung (Dioscorea hispida Dennst.) Tuber Chips using Leaching and Steaming Techniques [PDF]

open access: yes, 2011
Gadung (Dioscorea hispida Dennst.) has been considered as one of staple foods in Indonesia. However, its high cyanides content has limited its utilisation for commercial food production. This work is aimed to investigate the removal of cyanides content
Budiyati, C.S.   +2 more
core  

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