Results 41 to 50 of about 1,343,572 (337)

Effects of land cover, topography, and soil on stream water quality at multiple spatial and seasonal scales in a German lowland catchment

Ecological Indicators, 2021
The influence of catchment characteristics on water quality varies with space and time. Understanding the key factors influencing water quality is needed for effective land use and riparian management to protect river health.
Chaogui Lei, Paul D. Wagner, Nicola Fohrer   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Analysis of land use/land cover change trends over Birr River Watershed, Abbay Basin, Ethiopia

Environmental and Sustainability Indicators, 2023
Changes in land use/land cover (LULC) are a global environmental concern that has a significant impact on sustainable land and water resource management and development as well as hydrological processes.
Demelash Ademe Malede, Tena Alamirew, Job Rotich Kosgie, Tesfa Gebrie Andualem   +3 more
doaj   +1 more source

Arkansas Water Resources Research Center Pamphlet [PDF]

, 1990
Arkansas Water Resources Center (AWRC) works closely with state and federal agencies and academic institutions. Priority research categories are: surface water analysis, ground water pollution, surface and ground water quality/quanity, and water resource
Steele, Kenneth F.
core   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Investigating the extent of PFAS contamination in the Upper Danube Basin across environmental compartments

Environmental Sciences Europe
Background Per- and polyfluoroalkyl substances (PFAS) are emerging organic pollutants widely detected in environmental systems, posing risks to human health and the ecosystem.
Meiqi Liu, Ernis Saracevic, Thomas J. Oudega, Ali A. A. Obeid, Zsuzsanna Nagy-Kovács, Balázs László, Steffen Kittlaus, Ottavia Zoboli, Jörg Krampe, Julia Derx, Matthias Zessner   +10 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Estimation of Sugar Cane Evapotranspiration using SEBAL and SEBS Algorithms and Priestly-Taylor Method (Case Study of Amir Kabir Cultivation and Industry)

علوم آب و خاک, 2020
Agricultural water management studies require accurate information on actual evapotranspiration. This information must have sufficient spatial detail to allow analysis on the farm or basin level.
J. Jalili, F. Radmanesh, A. A. Naseri, M. A. Akhond Ali, H. A. Zarei   +4 more
doaj  

Importance of long-term cycles for predicting water level dynamics in natural lakes [PDF]

, 2015
Lakes are disproportionately important ecosystems for humanity, containing 77% of the liquid surface freshwater on Earth and comprising key contributors to global biodiversity.
Brennan, Michael, Donohue, Ian, García Molinos, Jorge, Viana, Mafalda   +3 more
core   +3 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source