Results 41 to 50 of about 161,767 (285)
Environmental Sciences EuropeBackground Per- and polyfluoroalkyl substances (PFAS) are emerging organic pollutants widely detected in environmental systems, posing risks to human health and the ecosystem.
Meiqi Liu +10 more
doaj +1 more source
Analysis of land use/land cover change trends over Birr River Watershed, Abbay Basin, Ethiopia
Environmental and Sustainability Indicators, 2023 Changes in land use/land cover (LULC) are a global environmental concern that has a significant impact on sustainable land and water resource management and development as well as hydrological processes.
Demelash Ademe Malede +3 more
doaj +1 more source
A methodological framework for the hydrological model selection process in water resource management projects [PDF]
, 2021 Diba Ghonchepour +5 more
openalex +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
علوم آب و خاک, 2020 Agricultural water management studies require accurate information on actual evapotranspiration. This information must have sufficient spatial detail to allow analysis on the farm or basin level.
J. Jalili +4 more
doaj
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells
FEBS Open Bio, EarlyView.Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori +8 more
wiley +1 more source
Waste Meretrix meretrix Shell as Adsorbent of Copper(Cu2+)
Journal of Tropical Life Science, 2022 Meretrix meretrixwas found to be a very abundant waste at Amal Beach, Tarakan City. M. meretrixwaste can reduce heavy metals, especially heavy metals copper (Cu2+), by the adsorption process.
Encik Weliyadi +2 more
doaj +1 more source
Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications
FEBS Open Bio, EarlyView.This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley +1 more source