Results 41 to 50 of about 175,584 (258)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Efficacy of Crude Extracts and Essential Oils of Selected Plants for the Management of Fall Armyworm (Spodoptera frugiperda) in Kenya

International Journal of Agronomy
Fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith), poses a serious threat to maize production in Kenya. This study aimed to assess the efficacy of crude extracts and essential oils of garlic (Allium sativum), red hot pepper (Capsicum frutescens ...
Catherine K. Mumo, Phyllis W. Muturi, Bernard M. Gichimu, Simon T. Mukono   +3 more
doaj   +1 more source

Modeling the spatio-temporal flow dynamics of groundwater-surface water interactions of the Lake Tana Basin, Upper Blue Nile, Ethiopia

Hydrology Research, 2020
The Ethiopian government has selected Lake Tana basin as a development corridor due to its water resources potential. However, combined use of groundwater (GW) and surface water (SW) is still inadequate due to knowledge gaps about the flow dynamics of GW
Tibebe B. Tigabu, Paul D. Wagner, Georg Hörmann, Nicola Fohrer   +3 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Estimation of Sugar Cane Evapotranspiration using SEBAL and SEBS Algorithms and Priestly-Taylor Method (Case Study of Amir Kabir Cultivation and Industry)

علوم آب و خاک, 2020
Agricultural water management studies require accurate information on actual evapotranspiration. This information must have sufficient spatial detail to allow analysis on the farm or basin level.
J. Jalili, F. Radmanesh, A. A. Naseri, M. A. Akhond Ali, H. A. Zarei   +4 more
doaj  

Re-suspension of bed sediment in a small stream – results from two flushing experiments [PDF]

Hydrology and Earth System Sciences, 2014
Streams draining small watersheds often exhibit multiple peaking sedigraphs associated with single peaking hydrographs. The process reasons of the multiple sediment peaks are not fully understood but they may be related to the activation of different ...
A. Eder, M. Exner-Kittridge, P. Strauss, G. Blöschl   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Effects of land cover, topography, and soil on stream water quality at multiple spatial and seasonal scales in a German lowland catchment

Ecological Indicators, 2021
The influence of catchment characteristics on water quality varies with space and time. Understanding the key factors influencing water quality is needed for effective land use and riparian management to protect river health.
Chaogui Lei, Paul D. Wagner, Nicola Fohrer   +2 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source