Results 41 to 50 of about 2,873,200 (314)

Hydrological modeling of floods in the Wadi Bechar watershed and evaluation of the climate impact in arid zones (southwest of Algeria)

Applied Water Science, 2018
Precise knowledge regarding the quantities of water available in the Wadi Bechar watershed and better management of this resource is necessary to initiate the transformation of rainfall data into hydrometric data (simulated flow); this is the main ...
Abdelghani Bekhira, Mohammed Habi, Boutkhil Morsli   +2 more
doaj   +1 more source

Social impact analysis of potential geothermal resource areas : Circular C-104 [PDF]

, 1984
Summary of social impacts associated with development of geothermal resources on lands for which Geothermal Resource Subzones were ...
State of Hawaii. Department of Land and Natural Resources, Division of Water and Land Development
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A Policy Development Perspective on Drinking Water Policy [PDF]

, 2012
This paper seeks to address the lack of knowledge in the water industry of how policy development can be understood to have shaped the development and application of European Union (EU) drinking water policy.
Jenkins, James
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Utilization of satellite data in determining hydropower potential to support energy security in new capital city region of Indonesia

Frontiers in Earth Science
The relocation of the national capital from DKI Jakarta to the East Kalimantan region and its people migration requires energy escalation. This project will require an additional 1,555 MW of electricity from existing conditions.
Arno Adi Kuntoro, Azman Syah Barran Roesbianto, Mohammad Farid, Hadi Kardhana, Faizal Immaddudin Wira Rohmat, Akbar Rizaldi, Muhammad Syahril Badri Kusuma, Mohammad Bagus Adityawan, Ahmad Nur Wahid   +8 more
doaj   +1 more source

Economic impact analysis of potential geothermal resource areas [PDF]

, 1984
Summary of economic impacts associated with development of geothermal resources on lands for which Geothermal Resource Subzones were ...
State of Hawaii. Department of Land and Natural Resources, Division of Water and Land Development
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source