Results 101 to 110 of about 948,205 (308)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Mix proportion optimization of cement flyash-water glass grouting material based on response surface method [PDF]

AIP Advances
In the process of tunnel construction and operation, fissure water inrush disasters occur frequently, seriously threatening the safety and construction efficiency of the project.
Tong Wu, Xue Yang, Jianghong Xu
doaj   +1 more source

From Waste to Treasure Trove: High-Value Cellulose-Rich Materials with Exceptional Water Retention Properties in Soil

Environmental Research
Droughts represent a critical environmental stressor with cascading effects on hydrology, agriculture, ecosystem integrity, and societal stability. Characterized by prolonged deficits in precipitation, they reduce water availability, impair crop yields, elevate wildfire risk, and destabilize socio-economic systems through resource scarcity.
Sundus Saeed Qureshi, Jia Xu, Tony Vancov, Chengrong Chen   +3 more
openaire   +2 more sources

TRIVALENT CHROMIUM (CR+3) IN DIETARY CARBOHYDRATE AND ITS EFFECT ON THE GROWTH OF COMMONLY CULTIVATED FISH [PDF]

, 2016
Trivalent chromium (Cr+3) is an essential trace mineral for fish bio-physiological functions. Researches on Cr+3 in the form of organic compound indicated that the mineral affected the bio-activity of insulin, the blood glucose influx, and subsequently ...
Hastuti, Sri, Subandiyono, Subandiyono
core  

Defluoridation of drinking water by electrocoagulation/electroflotation in a stirred tank reactor with a comparative performance to an external-loop airlift reactor [PDF]

, 2009
Defluoridation using batch electrocoagulation/electroflotation (EC/EF) was carried out in two reactors for comparison purpose: a stirred tank reactor (STR) close to a conventional EC cell and an external-loop airlift reactor (ELAR) that was recently ...
Bennajah, Mounir, Delmas, Henri, Essadki, Abdel Hafid, Gourich, Bouchaib, Vial, Christophe   +4 more
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Wetting water retention behaviors of intact loess under isotropic compression stress

Yantu gongcheng xuebao, 2018
The wetting tests by stages on intact loess with natural state are performed under different isotropic compression stresses by using the refitted triaxial equipment for shearing and permeability measurement of unsaturated soil. The influences of stresses
ZHANG Deng-fei 1, 2, CHEN Cun-li 1,2, ZHANG Jie 3, LIU Ke 4, YOU Zi-long 1, CHEN Cheng 1
doaj   +1 more source

Modeling nitrogen loadings from agricultural soils in southwest China with modified DNDC [PDF]

, 2011
Degradation of water quality has been widely observed in China, and loadings of nitrogen (N) and other nutrients from agricultural systems play a key role in the water contamination.
Deng, Jia, Li, Changsheng, Tang, Jialiang, Wang, Tao, Zheng, Xunhua, Zhou, Zaixing, Zhu, Bo   +6 more
core   +3 more sources