Results 111 to 120 of about 948,205 (308)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Practical measures for reducing phosphorus and faecal microbial loads from onsite wastewater treatment system discharges to the environment:a review [PDF]

, 2015
Onsite wastewater treatment systems (OWTS), the majority of which are septic tanks, are a contributing factor to phosphorus and faecal microbial loads. OWTS contribute to waterbodies failing to meet Water Framework Directive (WFD) objectives and as such,
Akunna, Joseph, Allan, Richard, Bruce, Alannah, May, Linda, O'Keeffe, Juliette, Olszewska, Justyna   +5 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Assessment and Valuation of Nutrient Retention Ecosystem Service in the International Mangrove Wetland of Khorkhoran Using the invest NDR Model and Avoided Cost Method [PDF]

محیط زیست و توسعه فرابخشی
Introduction: The international mangrove wetland of Khurkhoran on the southern coast of Iran, plays an important role in absorbing and stabilizing the retention of nutrients such as nitrogen and phosphorus, which reduces pollution of water resources and ...
Ardavan Zarandian, Roya Mousazadeh, Majid Ramezani Mehrian, Fatemeh Mohammadyari, Mohammad Sadegh Saba, Seyedeh Mahtab Shojaei Langari   +5 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Retention factor variation on wide range of mobile phase compositions in reversed-phase high-performance liquid chromatography; a short tutorial

Journal of Chromatography Open
Mobile phase composition remains the major experimental parameter influencing the separation process in reversed-phase high-performance liquid chromatography (RP-HPLC).
Victor David, Serban C. Moldoveanu
doaj   +1 more source

Influence of thermal wood modification on the Water Retention Value (WRV)

, 2018
Thermal modification of wood (ash, beech, spruce) leads to a remarkable decrease in the Water Retention Value (WRV). In case of beech wood the WRV-value decreased after immersion in water for 72 h from 55.5% to 40.5% (about 27%) and in case of spruce wood from 49.3% to 34.5% (about 30%). The decrease in the WRV of ash wood was relatively low (about 19%)
Roffael, Edmone, Kraft, R.
openaire   +1 more source

Comments on “Retention of Ionizable Compounds on HPLC. pH Scale in Methanol−Water and the pK and pH Values of Buffers” [PDF]

Analytical Chemistry, 1997
Article commenting on an article titled, "Retention of Ionizable Compounds on HPLC. pH Scale in Methanol-Water and the pK and pH Values of Buffers."
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The influence of changes in water content on the electrical resistivity of a natural unsaturated loess [PDF]

, 2012
Non-destructive methods of measuring water content in soils have been extensively developed in the last decades, especially in soil science. Among these methods, the measurements based on the electrical resistivity are simple and reliable thanks to the ...
Cui, Yu Jun, Delage, Pierre, Munoz-Castelblanco, José, Pereira, Jean-Michel   +3 more
core   +3 more sources