Results 41 to 50 of about 1,014,558 (255)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Revisiting hydrophobicity and its effectiveness in oil retention using microfluidic experiments
npj Clean WaterWe examined oil-water displacement under constant pressure difference conditions, simulating natural aquifer environments using microfluidic chips with different wettability and pore geometries. The results showed lower oil retention in hydrophobic chips
Kyung-Jin Lee +4 more
doaj +1 more source
LHB Hydroscience JournalIn view of the subjectivity and limitations of scenario setting, as well as the time-consuming nature of computations and difficulty of obtaining global optimal solutions, this paper proposes an ecological water replenishment optimisation model by ...
Yuhang Liang +7 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
A national-scale database of groundwater level data for Switzerland
Scientific DataGroundwater is a vital component of the global supply of freshwater, playing a critical role for human populations, agriculture, and ecosystems. Due to the complex interactions between groundwater, surface water, climate, and human activity, these ...
Raoul A. Collenteur +3 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Identification of new EphA4 inhibitors by virtual screening of FDA-approved drugs
Scientific Reports, 2018 The receptor tyrosine kinase, erythropoietin-producing hepatocellular A4 (EphA4), was recently identified as a molecular target for Alzheimer’s disease (AD).
Shuo Gu +6 more
doaj +1 more source
FACETS, 2021 Metformin is a glucose-lowering drug taken for diabetes. It is excreted by humans in urine and detected in municipal wastewater effluents and rivers.
Joanne L. Parrott +7 more
doaj +1 more source