Results 41 to 50 of about 1,114,301 (300)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Water Resources Science and Technology Fall Seminar Series: Steven Siebert (San Antonio Water System)

open access: yes, 2023
Mr. Steven Siebert gave the audience an in-depth introduction of the mission and service capacity of San Antonio Water System (SAWS), as well as SAWS water planning for the next 5 years and beyond. He touched on the local, regional, and state level water
Institute for Water Resources Science and Technology   +1 more
core  

Adsorption/desorption atmospheric water harvester

open access: yes, 2022
Harvesting water from ambient air has been an emerging technology to address the critical challenge of water shortage at a global scale. In a recent study published in Cell Reports Physical Science, Wang and colleagues created a novel solar-driven ...
Renyuan Li   +5 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Water Resources Science and Technology Fall Seminar Series: Gregg Eckhardt (San Antonio Water System)

open access: yes, 2022
Mr. Eckhardt is a true veteran of the San Antonio Water System. A native of San Antonio, he has a passion for the history of the Edwards Aquifer and the role it plays in the water management framework for San Antonio as the area developed over the ...
Eckhardt, Gregg   +1 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

High-Performance Computational Early Warning Analysis of Agricultural Economy Relying on Binary Fuzzy Cluster Analysis Algorithm

open access: yesJournal of Mathematics, 2021
In this paper, a binary fuzzy cluster analysis algorithm is used for an in-depth study and analysis of high-performance computational early warning in the agricultural economy.
Fang Tang
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Optimisation plan for ecological water replenishment in water-deficient rivers – a case study of Yongding River, China

open access: yesLHB Hydroscience Journal
In view of the subjectivity and limitations of scenario setting, as well as the time-consuming nature of computations and difficulty of obtaining global optimal solutions, this paper proposes an ecological water replenishment optimisation model by ...
Yuhang Liang   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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