Results 101 to 110 of about 2,993,457 (339)

Agricultural water management in a water stressed catchment: Lessons from the RIPARWIN Project [PDF]

open access: yes
irrigation management / water stress / river basins / water rights / water fees / water allocation / irrigation efficiency / economic aspects / decision support tools / wetlands / water use / water users ...
Lankford, B. A.   +2 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Preharvest Water Stress for Valley Sugar Beets

open access: yesCalifornia Agriculture, 1965
Moderate water stress prior to sugar beet harvest did not significantly reduce sugar production in Kern County tests. Higher sugar content of roots and lower production costs could make this practice profitable, if stress is not prolonged.
G Ferry, F Hills, R Loomis
doaj  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Improved Phosphorus Bioavailability in Lettuce Crop via Naganishia albida Inoculation of Wastewater-Derived Struvite

open access: yesAgronomy
Phosphorus (P) is a vital element for optimal crop growth and agricultural productivity. Struvite, a P precipitate obtained from wastewater, is recognized as a slow-release, low-solubility fertilizer.
Valentina Carrillo   +7 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Earthquakes: from chemical alteration to mechanical rupture

open access: yes, 1998
In the standard rebound theory of earthquakes, elastic deformation energy is progressively stored in the crust until a threshold is reached at which it is suddenly released in an earthquake.
Abercrombie   +276 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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