Results 171 to 180 of about 9,328,709 (366)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The Artesian Water-Supply of Australia from a Geographical Standpoint: Discussion [PDF]

, 1902
Lord Lamington, T. Fowell Buxton, Hugh Robert Mill, Mr. Langler, Gibbons Cox, Robert L. Jack   +5 more
openalex   +1 more source

Annual Financial Statements, 2007 [PDF]

, 2008
This resource is one among many in the UMSLCAB open dataset at IRL.UMSL.edu/CABhttps://irl.umsl.edu/cab/1702/thumbnail ...
Public Water Supply District C1 of Jefferson County
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Assessing institutional sanitation and its impact at a citywide level: an exploration of school sanitation in the Accra Metropolitan Area, Ghana

Frontiers in Environmental Science
IntroductionExploring sanitation at a city scale is crucial due to approaches such as Citywide Inclusive Sanitation (CWIS). Sanitation impacts individuals, households and the whole city, as recognised by CWIS.
William Nkonde, William Nkonde, Claire Furlong, Brian Reed, Damir Brdanovic   +4 more
doaj   +1 more source

Optimizing intermittent water supply in urban pipe distribution networks [PDF]

arXiv, 2015
In many urban areas of the developing world, piped water is supplied only intermittently, as valves direct water to different parts of the water distribution system at different times. The flow is transient, and may transition between free-surface and pressurized, resulting in complex dynamical features with important consequences for water suppliers ...
arxiv  

Water supply in relation to disease [PDF]

, 1878
Charles Henry Bromby
openalex   +1 more source

Assessing groundwater quality for drinking water supply using hybrid fuzzy-GIS-based water quality index.

Water Research, 2020
M. Jha, A. Shekhar, M. Jenifer
semanticscholar   +1 more source

State of the Groundwater Resources of Southern Oahu [PDF]

, 1980
This report was written by John F. Mink.--P.
Honolulu (Hawaii). Board of Water Supply, Mink, John F. (John Francis),1924-   +1 more
core  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source