Results 31 to 40 of about 468,655 (259)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Survey of Programs for Water-Surface Profiles

Journal of the Hydraulics Division, 1970
Several highly developed computer programs are available for determining water surface profiles for subcritical flow in rivers and channels. The needs for fast, accurate and inexpensive computation of profiles, and for more sophisticated techniques, can be satisfied by computer programs currently being developed. Current capabilities and limitations of
openaire   +2 more sources

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

An attempt to find a suitable place for soil moisture sensor in a drip irrigation system

Information Processing in Agriculture, 2022
Determination of an appropriate location for monitoring soil water content (SWC) is a key factor in efficient use of water in precision agriculture, however, the main challenge is the dynamic movement of water and root development in the soil profile ...
Zahra Amiri, Mahdi Gheysari, Mohammad Reza Mosaddeghi, Samia Amiri, Mahsa Sadat Tabatabaei   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Impact of partially filled pipes on hydraulic performance of canal-pipe water delivery systems

Guan'gai paishui xuebao
【Objective】 Changes in water pressure in pipe networks can cause partial filling of pipes, leading to non-full flow. The objective of this paper is to investigate the impact of non-full flow on the hydraulic performance of canal-pipe water delivery ...
LI Rui, LYU Mouchao, JIA Xiaomeng, WANG Hongfei   +3 more
doaj   +1 more source

Investigation of Optimum Heat Flux Profile Based on the Boiling Safety Factor

Journal of Engineering, 2019
An experimental study is conducted to investigate the effect of heat flux distribution on the boiling safety factor of its cooling channel. The water is allowed to flow in a horizontal circular pipe whose outlet surface is subjected to different heat ...
Akram W. Ezzat, Sajida Lafta Ghashim
doaj   +1 more source

Effect of vertical velocity profile approximations on estimates of dam breach discharge using surface velocities

Journal of Flood Risk Management, 2021
In order to investigate the relationship between water surface velocity and breach hydrograph, a series of dam breach experiments with a generalised landslide dam were conducted in an open channel of 50 m × 4 m × 2 m.
Jie Liu, Hong Xiao, Pengzhi Lin, Chuanxing Zhou, Wei Wang   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source