Results 121 to 130 of about 2,565,844 (218)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Climate and water-table levels regulate peat accumulation rates across Europe. [PDF]

PLoS One
Swindles GT, Mullan DJ, Brannigan NT, Fewster RE, Sim TG, Gallego-Sala A, Blaauw M, Lamentowicz M, Jassey VEJ, Marcisz K, Green SM, Roland TP, Loisel J, Amesbury MJ, Blundell A, Chambers FM, Charman DJ, Evans CRC, Feurdean A, Galloway JM, Gałka M, Karofeld E, Keaveney EM, Korhola A, Lamentowicz Ł, Langdon P, Mauquoy D, McKeown MM, Mitchell EAD, Plunkett G, Roe HM, Turner TE, Sillasoo Ü, Väliranta M, van der Linden M, Warner B.   +35 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Biochar mitigates the peatland GHG dilemma under contrasting water table regimes: phase-dependent responses of CO₂ and CH₄ over a two-year study. [PDF]

Biochar
Jeewani PH, Rhymes JM, Evans CD, Jones DL, Chadwick DR.   +4 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Wetter farming: raising water table and biochar for reduced GHG emissions while maintaining crop productivity in agricultural peatlands. [PDF]

Biochar
Jeewani PH, Agbomedarho EO, Evans CD, Chadwick DR, Jones DL.   +4 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Using Expert Participation to Evaluate the Accuracy of Hand-Drawn Water-Table Maps. [PDF]

Ground Water
Marshall SK, Peeters LJM, Batelaan O, Noorduijn S, Velterop T.   +4 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Research on water body information extraction and monitoring in high water table mining areas based on Google Earth Engine. [PDF]

Sci Rep
Zhong A, Wang Z, Gen Y.
europepmc   +1 more source