Results 91 to 100 of about 2,557,612 (293)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Practical implementation of the entropy index in assessing the ecological state of water ecosystems
Водное хозяйство России: проблемы, технологии, управлениеAssessment of the biological systems’ state in case of anthropogenic impact is the most important aspect of monitoring of the surface waters’ state and pollution. The state of more than 100 water bodies of the European territory of Russia and Siberia was
Mikhail M. Trofimchuk
doaj +1 more source
Revista Colombiana de Ciencias Pecuarias, 2011 Con el fin de atender la creciente demanda del mercado, la acuicultura se ha expandido mediante la implementación de sistemas de cultivo intensivo que requieren suministro de altas cantidades de alimento.
Rubén D Valbuena-Villarreal +1 more
doaj
Archives of Polish Fisheries, 2018 This paper is focused on horizontal, vertical, and temperature-dependent distributions, size composition of bottom and mid-water trawl catches, and biomass estimations of smooth lumpsucker Aptocyclus ventricosus (Pallas) (Cyclopteridae) within the ...
Solomatov Sergei F., Orlov Alexei M.
doaj +1 more source
, 2009 Includes bibliographical references.Temperature is an important environmental variable for aquatic invertebrates as it affects their development, reproduction and survival.
Ketley, Zoma Anne
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2015 Funding for this research came from The Buckland Foundation, The Scottish Fisheries Museum Trust Ltd. Additional costs and supplies were provided by the School of Biology of The University of St Andrews.Guppies have successfully established populations ...
Kent, Maud +3 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Factors affecting water quality from strip-mined sites
, 1976 This project analyzed the parameters that influence the quality of water from strip-mined sites. An instrumented watershed near Beckley, W. Va., provided data on precipitation, stream flow, and water quaIity, both before and during mining operations ...
Connell, J. F. +2 more
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source