Results 101 to 110 of about 11,786,465 (330)

Oceanographic observations in the Nordic Sea and Fram Strait in 2016 under the IO PAN long-term monitoring program AREX

open access: yesOceanologia, 2017
Since 1987 annual summer cruises to the Nordic Seas and Fram Strait have been conducted by the IO PAN research vessel Oceania under the long-term monitoring program AREX.
Waldemar Walczowski   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Water in the 2007 Virginia General Assembly

open access: yes, 2007
The 2007 Virginia General Assembly convened January 10, adjourned February 24, and held a reconvened (“veto”) session on April 4. During the session, the Assembly considered 3427 measures (3069 introduced in this session and 358 continued from the 2006 ...
Virginia Water Resources Research Center
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Water in the 2000 Virginia General Assembly

open access: yes, 2000
The Virginia General Assembly held its 2000 session from January 12 to March 10. Lawmakers considered 3,172 bills and resolutions (compared to 2,735 measures considered in 1999).
Virginia Water Resources Research Center
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Water in the 2005 Virginia General Assembly

open access: yes, 2005
The 2005 Virginia General Assembly convened January 12 and adjourned February 27, with a reconvened (“veto”) session on April 6. The legislature considered 3363 measures (2938 introduced this year and 425 carried over from last year); 1610 measures ...
Virginia Water Resources Research Center
core  

Evaluation of the impacts of turbidity on Gilgel-Gibe I reservoir storage, Omo-Gibe River Basin, Ethiopia

open access: yesHeliyon
Quantity and quality of the water held in the reservoir fluctuates due to turbidity alterations. The influence of turbidity on the amount of the water held in a reservoir was described explicitly in this research. This study aimed to evaluate turbidity's
Aduna Birmachu   +2 more
doaj   +1 more source

Analytical study on abnormal change in time-variable gravity at Yichang seismostation before the M5.1 Badong earthquake

open access: yesGeodesy and Geodynamics, 2014
An M5.1 earthquake occurred in Badong County, only 66 km from the Three Gorges Dam, on December 16, 2013. The continuous gravity observation data obtained at Yichang seismostation nearest to the epicenter (96 km) were analyzed, and it was found that the ...
Wei Jin   +3 more
doaj   +1 more source

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