Results 41 to 50 of about 13,606,163 (264)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Valuable elements in sludge from eight municipal wastewater treatment plants in relation to their recovery potential

Environmental Sciences Europe
Background The management of sludge from municipal wastewater treatment plants (WWTPs) is a global issue, but also an opportunity for circular reuse. Recent data show that sludge reuse in agriculture has the highest share of all utilization routes in the
Dobril Valchev, Irina Ribarova, Boyan Borisov, Viden Radovanov, Valentina Lyubomirova, Irina Kostova, Galina Dimova, Orhideya Karpuzova, Svetlana Lazarova   +8 more
doaj   +1 more source

Particle Size Matters: Distribution, Source, and Seasonality Characteristics of Airborne and Pathogenic Bacteria in Wastewater Treatment Plants

Atmosphere, 2023
Wastewater treatment plants (WWTPs) are a crucial source of bioaerosols, which account for both environmental and health hazards. Although various culture-based studies on bioaerosols have been reported, little knowledge remains about distribution and ...
Jianan Wan, Zhiruo Zhang, Yang Huo, Xianze Wang, Yifan Wang, Jinghui Wu, Mingxin Huo   +6 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Potential evaluation and perspectives on using sponge-like superabsorbent cryogels for onsite water treatment in emergencies

, 2014
This paper reports and discusses the prospects of a novel approach for emergency water treatment using antibacterial PSA/Ag cryogels. The approach involves allowing the cryogel to swell in contaminated water after which the disinfected water can be ...
Lim, Teik-Thye, Fane, Anthony G., Loo, Siew-Leng, Krantz, William B., Hu, Xiao   +4 more
core   +1 more source

Dual-Ionization SPME-GC–HRMS Metabolomic Profiling of Broccoli Volatiles for the Construction of a Broccoli Metabolic Database

Molecules
Volatile organic compounds (VOCs) play critical roles in broccoli’s sensory attributes, defense mechanisms, and ecological interactions, yet comprehensive profiling of its volatilome remains limited.
Chenxue Song, Meijia Yan, Sue Lin, Junliang Li, Huixi Zou, Zhiwei Hu, Xiufeng Yan   +6 more
doaj   +1 more source

Application of Metallic Iron and Ferrates in Water and Wastewater Treatment for Cr(VI) and Organic Contaminants Removal

Resources, 2023
Iron species can act as electron donors, electron acceptors or serve as a sorbent to co-precipitate contaminants. These properties, along with its relatively low cost as a material, make iron an ideal compound for environmental applications in the ...
Georgios Samiotis, Adam Stimoniaris, Ilias Ristanis, Liana Kemmou, Charoula Mavromatidou, Elisavet Amanatidou   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source