Results 51 to 60 of about 2,659,137 (363)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Water and radiation use efficiencies of irrigated biomass sorghum in a Mediterranean environment

Italian Journal of Agronomy, 2011
Biomass sorghum (Sorghum bicolor L. Moench) is a crop that can be used for energy production in the bioethanol chain and a greater knowledge of its potential and response to irrigation water levels could help to assess its potential diffusion in ...
Pasquale Garofalo, Alessandro Vittorio Vonella, Sergio Ruggieri, Michele Rinaldi   +3 more
doaj   +1 more source

Wind increases leaf water use efficiency

Plant, Cell & Environment, 2016
AbstractA widespread perception is that, with increasing wind speed, transpiration from plant leaves increases. However, evidence suggests that increasing wind speed enhances carbon dioxide (CO2) uptake while reducing transpiration because of more efficient convective cooling (under high solar radiation loads).
Stanislaus J, Schymanski, Dani, Or
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Nonparametric approach for measuring the productivity change and assessing the water use efficiency in the irrigated areas of Tunisia [PDF]

In order to cope with the water scarcity, Tunisia has to manage efficiently the demand of the economic and social sectors mainly that of the agricultural irrigated activities. Within this context our investigation aims to analyze the technical efficiency,
Chemak, Fraj
core   +4 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Groundwater markets and water use efficiency: The case of Karnataka [PDF]

Research highlight based on a paper titled “Groundwater markets promoting efficiency in water use in agriculture in Karnataka.”Water market, Groundwater extraction, Water use efficiency, Wells, Crop production, Irrigation water, Domestic water, Pricing ...
Chandrakanth, Mysore G., Deepak, S.C., Nagaraj, N.   +2 more
core   +4 more sources

Global patterns, trends, and drivers of water use efficiency from 2000 to 2013 [PDF]

, 2015
Water use efficiency (WUE; gross primary production [GPP]/evapotranspiration [ET]) estimates the tradeoff between carbon gain and water loss during photosynthesis and is an important link of the carbon and water cycles.
Guo, Qinghua, Li, Le, Otto, Alvarez, Tao, Shengli, Xiao, Jingfeng, Xue, Bao-Lin   +5 more
core   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source