Results 41 to 50 of about 7,136,512 (247)
Water management and smallholder Fairtrade tea producers in South Western Uganda [PDF]
, 2007 Kayonza growers’ tea factory is a remote tea factory in south western Uganda which consists of two core estates and 4072 smallholder tea farmers currently producing tea over a total area of 1604 hectares.
Flowers, Cara
core +4 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
AgronomyAs a typical reforested region of the Loess Plateau, the Caijiachuan watershed plays a vital role in ecological security and resource management. This study evaluates the spatiotemporal variations in key ecosystem services—namely soil retention, water ...
Guiyun Song +5 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Assessment of hydrology, sediment and particulate organic carbon yield in a large agricultural catchment using the SWAT model [PDF]
, 2011 The Soil and Water Assessment Tool (SWAT, 2005) was used to simulate discharge and sediment transport at daily time steps within the intensively farmed Save catchment in south-west France (1110 km2).
Simeoni-Sauvage, Sabine +6 more
core +1 more source
Frontiers in Environmental ScienceEconomic performance is traditionally assessed through the System of National Accounts (SNA), with Gross Domestic Product (GDP)—the annual aggregated market value of a country’s goods and services—as its most widely used indicator.
Daniel Pinillos +8 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source