Results 161 to 170 of about 718,014 (391)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Watershed development projects in India: an evaluation [PDF]
Watershed development., Watershed management India., Natural resources India Management., Poverty alleviation South Asia.,
Kerr, John
core
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Optimal Provision and Finance of Ecosystem Services: the Case of Watershed Conservation and Groundwater Management [PDF]
Payments for ecosystem services should be informed by how both the providing-resource and the downstream resource are managed. We develop an integrated model that jointly optimizes conservation investment in a watershed that recharges a downstream ...
Christopher Wada, James Roumasset
core
Watersheds – Functions and Management
EDIS, 1969 The term watershed is often used in discussions about water quality or flood prevention, but most people do not really understand what a watershed is. The definition of a watershed is based on a concept with which everyone is familiar: “Water runs downhill.” A Watershed is a land area whose runoff drains into any stream, river, lake, and ocean ...
openaire +5 more sources
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Water quality issues in the Illinois River watershed: A proposal for new voluntary incentives [PDF]
, 2006 Concerns about water quality degradation exist in Northwest Arkansas. The purpose of this study was to analyze the potential usefulness of U.S. conservation programs in addressing water quality concerns on farms in the Illinois River watershed as well as
Hodges, Tory B., Popp, Jennie S.
core +2 more sources
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Socio-economic and Environmental Perspectives of Sustainable Watershed Eco-System in Union Territory of Pondicherry [PDF]
The study conducted in the Karaikal region of the Union Territory of Pondicherry during 2004-05 has made a comparison of watershed and conventional systems.
Mahesh, N., Nasurudeen, P.
core +1 more source