Results 91 to 100 of about 291,995 (311)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Concentration-discharge relationships derived from a larger regional dataset as a tool for watershed management. [PDF]

Ecol Appl, 2021
D'Amario SC, Wilson HF, Xenopoulos MA.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Integrating Forest Conservation and Food Security: Managing Flood and Drought in Northern Thailand under CMIP5 Climate Projections

Jurnal Sylva Lestari
Increasing food demand and climate change-induced natural disasters pose significant challenges to food security. This study examines how forest conservation can mitigate disaster risks to agricultural land in Northern Thailand’s watershed.
Muhammad Chrisna Satriagasa, Piyapong Tongdeenok, Naruemol Kaewjampa   +2 more
doaj   +1 more source

Extended Water Quality Monitoring of the Lincoln Lake Watershed [PDF]

, 2000
For seven years, the Lincoln Lake (Moores Creek and Beatty Branch) watershed was monitored for improvements in water quality resulting from agricultural best management practices (BMP) implemented to reduce nutrient transport.
Cash, L. W., NcNew, R. W., Nelson, M. A., Steele, K. F., Vendrell, Paul F.   +4 more
core   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Risk Based Urban Watershed Management Under Conflicting Objectives [PDF]

, 2001
Ecological impairment and flooding caused by urbanization can be expressed numerically by calculating the risks throughout the watershed (floodplain) and along the main stems of the streams.
Booth, Douglas, Clark, David E., Griffin, Robert, Novotny, Vladimir   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Environmental Effects of Watershed Modifications [PDF]

Watershed management is more effective when there is a relief from the population to exploit the land. Undoubtedly, such policies must be premised on a full appreciation of the interdependence and the extent of interaction of the various components of ...
David, Wilfredo P.
core  

Quantification of land-use impact on stream water quality [PDF]

, 2002
Accelerated eutrophication of Beaver Lake in northwest Arkansas is a major environmental concern. When developing watershed-management plans to protect lake water quality, it is important that linkages among land-use activities and water quality of ...
Chaubey, Indrajeet, Dennis, Scott, Haggard, Brian   +2 more
core   +2 more sources