Results 41 to 50 of about 435,759 (309)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

CFD modeling of orthogonal wave-current interactions in a rectangular numerical wave basin

Advances in Bridge Engineering
Sea-crossing bridges are subject to long-term simultaneous wave and current loadings throughout thier life cycle. The wave-current interaction makes the hydrodynamic load calculation difficult and challenging, especially in simulating the noncollinear ...
Kai Wei, Kaiyu Hu
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Evaluating the Effects of Water Circulation on the Modeling of Wave Propagation on the Southern Coast of the Iberian Peninsula

Journal of Marine Science and Engineering
Simulating wave propagation is crucial for forecasting processes offshore and near the coast. Many operational wave models consider only atmospheric and wave forcing as boundary conditions.
Lara Mills, Juan L. Garzon, Flávio Martins   +2 more
doaj   +1 more source

An Integrated Approach to Study the Morphodynamics of the Lignano Tidal Inlet

Journal of Marine Science and Engineering, 2020
The morphological evolution of a tidal inlet is the combined result of tides and wind waves, which interact in a non-linear manner and over very different time-scales. Likewise, the presence of maritime structures built in the vicinity of the tidal inlet,
Marco Petti, Silvia Bosa, Sara Pascolo, Erika Uliana   +3 more
doaj   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

Modelling Wave-current Interaction and Its Potential Influence on the Transport of Materials in Lake Taihu, China

, 2016
A wave-current coupled model was established to investigate the interaction of wind-induced wave and current and its potential effect on the transport of materials in Lake Taihu, China. Different wind conditions were considered, and numerical experiments
姚波, Yao, B (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing 100190, Peoples R China., 刘青泉   +2 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Modelling longshore sediment transport under asymmetric waves

Oceanologia, 2006
Two wave theories are applied in calculations of longshore sediment transport rates: the second Stokes approximation and the cnoidal theory. These approaches are used to model sand motion in nearshore locations beyond and within the surf zone.
Rafał Ostrowski, Marek Szmytkiewicz
doaj