Results 41 to 50 of about 146,835 (265)

Comparative Analysis of High-Fidelity and Reduced-Order Models for Nonlinear Wave–Bathymetry and Wave–Structure Interactions

Journal of Marine Science and Engineering
This paper presents a computational study of wave–bathymetry and wave–structure interaction problems using advanced numerical techniques based on high-fidelity, two-phase Navier–Stokes (TpNS) flow and reduced-order, fully nonlinear potential flow models.
Wen-Huai Tsao, Christopher E. Kees
doaj   +1 more source

Smoothed Particle Hydrodynamics Simulation of Wave Overtopping Characteristics for Different Coastal Structures

The Scientific World Journal, 2012
This research paper presents an incompressible smoothed particle hydrodynamics (ISPH) technique to investigate a regular wave overtopping on the coastal structure of different types.
Jaan Hui Pu, Songdong Shao
doaj   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Smoothed Particle Hydrodynamics Modelling of Bergy Bit and Offshore Structure Interactions Due to Large Waves

Journal of Marine Science and Engineering
This research utilised an open-sourced smoothed particle hydrodynamics (SPH) tool to model and predict the change in wave-induced forces and motions of a free-floating bergy bits approaching a fixed structure in regular waves.
Mohammed Islam, Tanvir Sayeed
doaj   +1 more source

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

HAMS: A Frequency-Domain Preprocessor for Wave-Structure Interactions—Theory, Development, and Application

Journal of Marine Science and Engineering, 2019
This paper presents the theoretical background, the numerical implementation, and the applications of a new software that has been developed in recent years for the analysis of wave-structure interactions.
Yingyi Liu
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

A new numerical framework for large-eddy simulation of waves generated by objects piercing water surface

Theoretical and Applied Mechanics Letters, 2019
A novel numerical framework is developed for large-eddy simulation (LES) of interactions among air, water, and solid bodies. The motions of air and water are solved on a fixed block-structured mesh, with the air–water interface captured using the volume ...
Zixuan Yang, Zuo Cui, Shizhao Wang
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Estimation of the Motion Response of a Large Ocean Buoy in the South China Sea

Journal of Marine Science and Engineering
Ocean data buoys are among the most effective tools for monitoring marine environments. However, their measurement accuracy is affected by the motion of the buoys, making the hydrodynamic characteristics of buoys a critical issue.
Yunzhou Li, Chuankai Zhao, Penglin Jing, Bangqi Chen, Guanghua He, Zhigang Zhang, Jiming Zhang, Min Li, Juncheng Wang   +8 more
doaj   +1 more source