Results 51 to 60 of about 1,072,820 (299)

The effect of waves on rubble-mound structures [PDF]

open access: yes, 1975
For thousands of years breakwaters have been built at or near the coast to protect harbors or coastlines from wave attack. One of the earliest known harbor protection schemes was devised in about 2000 B.C.
Raichlen, Fredric
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

An experimental study on wave run-ups of fixed four-rounded-square-column array in focused waves

open access: yesJournal of Ocean Engineering and Science
The wave run-up along the column surface is one of the focal issues of research in ocean engineering. This experimental study aimed to reveal the wave run-up characteristics of a fixed four-square-column array with rounded corners under focused waves by ...
Meng Shan   +4 more
doaj   +1 more source

Resonance phenomena at the long wave run-up on the coast [PDF]

open access: yesNatural Hazards and Earth System Sciences, 2013
Run-up of long waves on a beach consisting of three pieces of constant but different slopes is studied. Linear shallow-water theory is used for incoming impulse evolution, and nonlinear corrections are obtained for the run-up stage.
A. Ezersky, D. Tiguercha, E. Pelinovsky
doaj   +1 more source

Wave Run-Up at Sea Dikes under Oblique Wave Approach

open access: yesCoastal Engineering 1982, 1982
Besides wave impact forces, erosion of the inner side of a sea dike is a serious cause of destruction. Therefore, wave run-up and overtopping effects have to be considered with respect to the safety of a dike. Strong relations were found between both these influences (TAUTENHAIN et.al., 1980, 1981, 1982), based on experiments in a wave flume and using ...
E. Tautenhain   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Wave run-up prediction and observation in a micro-tidal beach [PDF]

open access: yesNatural Hazards and Earth System Sciences, 2018
Extreme weather events bear a significant impact on coastal human activities and on the related economy. Forecasting and hindcasting the action of sea storms on piers, coastal structures and beaches is an important tool to mitigate their effects.
D. Di Luccio   +5 more
doaj   +1 more source

Prediction of Wave Run-up on a Coastal Impermeable Structure [PDF]

open access: yes, 2001
A knowledge of wave run-up behavior on a coastal structure is one of the most important factors affecting the design of coastal structures exposed to wave attack.
Hargono, S. (Slamet)   +1 more
core  

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

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