Results 101 to 110 of about 315,886 (312)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Examination of a novel wavelet based approach for bender element testing [PDF]

open access: yes, 2008
Presented at the 4th Symposium on Bridge & Infrastructure Research in Ireland, 4-5 December 2008, Galway, IrelandAccurate determination of shear wave arrival time using bender elements may be severely affected by a combination of near field effects and ...
Donohue, Shane   +2 more
core  

Research on the Effect of a Heave Plate on the Dynamics of the Floating Wind Turbine Using Model Tests

open access: yesJournal of Marine Science and Engineering
The increasing demand to harness offshore wind resources has pushed offshore wind turbines into deeper waters, making floating platforms more economically feasible than bottom-fixed ones.
Lidong Yang   +5 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian   +8 more
wiley   +1 more source

Propagator and wave-equation inversion for near-receiver material properties [PDF]

open access: yes, 2004
Near-receiver material properties are required for the separation of the recorded wavefield into upgoing and downgoing P and S waves, and are also important for static time-shift corrections.
Trampert, J.   +2 more
core   +1 more source

Hydraulic Model Tests on Modified Wave Dragon [PDF]

open access: yes, 2001
A floating model of the Wave Dragon (WD) was built in autumn 1998 by the Danish Maritime Institute in scale 1:50, see Sørensen and Friis-Madsen (1999) for reference.
Lynggaard, Jakob, Hald, Tue
core   +2 more sources

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay   +13 more
wiley   +1 more source

The prediction and back analysis of excavation behaviour in Oxford Clay. [PDF]

open access: yes, 1996
The work described in this thesis involved the prediction and back-analysis of ground movements and pore water pressures around a temporary excavation, lOm deep, 105m long and 35m wide (50m long and lOm wide at its base) in the heavily overconsolidated
Pierpoint, Nicholas David   +1 more
core  

Wave energy converter configuration in dual wave farms [PDF]

open access: yes, 2019
Wave farms, i.e., arrays of Wave Energy Converters (WECs), have recently been proven to be effective in fulfilling the dual function of carbon-free energy generation and coastal protection.
Allen, James   +3 more
core   +1 more source

Laboratory Side Effects of Haloperidol

open access: yesPsychiatry and Clinical Psychopharmacology, 2021
In this study, 21 subjects with schizophreniform disorder were given routine biochemical and hemathological laboratory tests along with prolactine, thyroid funtion tests, ECG and EEG, before and after 4 weeks of haloperidol treatment.
Servet EBRİNÇ   +3 more
doaj  

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