Results 131 to 140 of about 140,939 (365)

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

open access: yesAdvanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo   +15 more
wiley   +1 more source

Temperature-Insensitive Second-Order Microring Resonator for Dense Wavelength Division Multiplexing (DWDM)

open access: yesIEEE Photonics Journal
To achieve temperature-insensitive passband responses of microring resonator (MRR) for DWDM signal processing, we design and fabricate a wavelength division multiplexer with four channels based on 2nd-order slot MRR with PMMA cladding layer. Four filters
Fuling Wang   +4 more
doaj   +1 more source

Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker‐Based Drug Screening for Neurodegenerative Diseases

open access: yesAdvanced Science, EarlyView.
This work introduces an on‐chip, integrated plasmonic infrared microarray sensor that enables high‐throughput, label‐free drug screening targeting structural protein biomarkers in neurodegenerative diseases. Through ultra‐compact microwell arrays, the sensor achieves ultra‐sensitive, rapid, and multiplexed secondary structural analysis of the effect of
Deepthy Kavungal   +5 more
wiley   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang   +15 more
wiley   +1 more source

Flat-Top Eight-Channel Wavelength Division Demultiplexer for L-Band Optical Communication With Low Crosstalk

open access: yesIEEE Photonics Journal
We have demonstrated an eight-channel wavelength demultiplexer in the L-band based on a cascaded Mach-Zehnder interferometer (MZI) lattice filter fabricated on an 8-inch silicon nitride (SiN) photonics platform.
Yilin Zhong   +5 more
doaj   +1 more source

Distributed Acoustic Sensor Using a Double Sagnac Interferometer Based on Wavelength Division Multiplexing. [PDF]

open access: yesSensors (Basel), 2022
Zhirnov AA   +6 more
europepmc   +1 more source

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