Results 141 to 150 of about 42,500 (342)

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

open access: yesAdvanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun   +14 more
wiley   +1 more source

Precision‐Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart‐Warning of Weightlessness Induced Bone Loss

open access: yesAdvanced Science, EarlyView.
It is synthesized precision‐arranged DNA origami plasmonic nanoantennas for multiplexed and intelligent warning of bone loss induced by microgravity and radiation. The ordered nanoantennas simultaneously and accurately detected calcium ions, interleukin‐6, and microRNA‐214 in serum from mice exposed to microgravity and radiation, with performance ...
Yufan Ling   +14 more
wiley   +1 more source

Multifunctional Chiral Halide Perovskites: Advancing Chiro‐Optics, Chiro‐Optoelectronics, and Spintronics

open access: yesAdvanced Science, EarlyView.
This review spotlights key advances in chiral halide perovskite materials and devices, covering device architectures, fabrication methods, and emerging applications like circularly polarized light functions, neuromorphic computing, and spintronics. It explores structure‐property relationships and chirality transfer mechanisms, discusses challenges in ...
Qi Liu, Hui Ren, Qi Wei, Mingjie Li
wiley   +1 more source

High‐Speed Design of Multiplexed Meta‐Optics Enabled by Physics‐Driven Self‐Supervised Network

open access: yesAdvanced Science, EarlyView.
A physics‐driven self‐supervised network (PDSS‐Net) is proposed for high‐speed, iteration‐free design of multiplexed meta‐optics. By learning a direct mapping from holographic targets to all meta‐atom structures, PDSS‐Net achieves a 1000× speedup over traditional optimization methods in designing 2K RGB meta‐holograms.
Yuqing He   +7 more
wiley   +1 more source

Water‐Immersed GaP Huygens’ Meta‐Optics for Visible Structured Light Generation

open access: yesAdvanced Science, EarlyView.
Ultrathin GaP Huygens’ metasurfaces operating in the visible regime generate structured light beams underwater, including focusing Gaussian beams, abruptly autofocusing beams, Bessel beams, and optical vortices. The platform offers enhanced fabrication tolerance and mechanical stability, establishing a robust route toward compact underwater ...
Jia‐Hua Lee   +8 more
wiley   +1 more source

Deep Learning‐Assisted Coherent Raman Scattering Microscopy

open access: yesAdvanced Intelligent Discovery, EarlyView.
The analytical capabilities of coherent Raman scattering microscopy are augmented through deep learning integration. This synergistic paradigm improves fundamental performance via denoising, deconvolution, and hyperspectral unmixing. Concurrently, it enhances downstream image analysis including subcellular localization, virtual staining, and clinical ...
Jianlin Liu   +4 more
wiley   +1 more source

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